Evaluation of diagnostic test procedures for SARS-CoV-2 using latent class models.
J Med Virol
; 94(10): 4754-4761, 2022 10.
Article
in English
| MEDLINE | ID: covidwho-1894609
ABSTRACT
Polymerase chain reaction (PCR) and antigen tests have been used extensively for screening during the severe acute respiratory syndrome coronavirus 2 pandemics. However, the real-world sensitivity and specificity of the two testing procedures in the field have not yet been estimated without assuming that the PCR constitutes a gold standard test. We use latent class models to estimate the in situ performance of both tests using data from the Danish national registries. We find that the specificity of both tests is very high (>99.7%), while the sensitivities are 95.7% (95% confidence interval [CI] 92.8%-98.4%) and 53.8% (95% CI 49.8%-57.9%) for the PCR and antigen tests, respectively. These findings have implications for the use of confirmatory PCR tests following a positive antigen test result:
we estimate that serial testing is counterproductive at higher prevalence levels.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
Limits:
Humans
Language:
English
Journal:
J Med Virol
Year:
2022
Document Type:
Article
Affiliation country:
Jmv.27943
Similar
MEDLINE
...
LILACS
LIS