Simulation to minimise patient self-inflicted lung injury: are we almost there?
Br J Anaesth
; 129(2): 150-153, 2022 08.
Article
in English
| MEDLINE | ID: covidwho-1894821
ABSTRACT
Computational modelling has been used to enlighten pathophysiological issues in patients with acute respiratory distress syndrome (ARDS) using a sophisticated, integrated cardiopulmonary model. COVID-19 ARDS is a pathophysiologically distinct entity characterised by dissociation between impairment in gas exchange and respiratory system mechanics, especially in the early stages of ARDS. Weaver and colleagues used computational modelling to elucidate factors contributing to generation of patient self-inflicted lung injury, and evaluated the effects of various spontaneous respiratory efforts with different oxygenation and ventilatory support modes. Their findings indicate that mechanical forces generated in the lung parenchyma are only counterbalanced when the respiratory support mode reduces the intensity of respiratory efforts.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome
/
Lung Injury
/
COVID-19
Type of study:
Experimental Studies
Limits:
Humans
Language:
English
Journal:
Br J Anaesth
Year:
2022
Document Type:
Article
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