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SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patient.
Quaranta, Erika Giorgia; Fusaro, Alice; Giussani, Edoardo; D'Amico, Valeria; Varotto, Maria; Pagliari, Matteo; Giordani, Maria Teresa; Zoppelletto, Maira; Merola, Francesca; Antico, Antonio; Stefanelli, Paola; Terregino, Calogero; Monne, Isabella.
  • Quaranta EG; Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, Italy. Electronic address: equaranta@izsvenezie.it.
  • Fusaro A; Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, Italy.
  • Giussani E; Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, Italy.
  • D'Amico V; Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, Italy.
  • Varotto M; Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, Italy.
  • Pagliari M; Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, Italy.
  • Giordani MT; Infectious Diseases Unit, Alto Vicentino Hospital, ULSS 7 Pedemontana, Santorso, Vicenza, Italy.
  • Zoppelletto M; San Bassiano Hospital, ULSS 7 Pedemontana, Bassano del Grappa, Vicenza, Italy.
  • Merola F; San Bassiano Hospital, ULSS 7 Pedemontana, Bassano del Grappa, Vicenza, Italy.
  • Antico A; San Bassiano Hospital, ULSS 7 Pedemontana, Bassano del Grappa, Vicenza, Italy.
  • Stefanelli P; Department of Infectious Diseases, Istituto Superiore di Sanità, Roma, Italy.
  • Terregino C; Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, Italy.
  • Monne I; Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, Italy.
Int J Infect Dis ; 122: 444-448, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1895084
ABSTRACT

OBJECTIVES:

Intra-host SARS-CoV-2 evolution during chronic infection in immunocompromised hosts has been suggested as being the possible trigger of the emergence of new variants.

METHODS:

Using a deep sequencing approach, we investigated the SARS-CoV-2 intra-host genetic evolution in a patient with HIV over a period of 109 days.

RESULTS:

Sequencing of nasopharyngeal swabs at three time points demonstrated dynamic changes in the viral population, with the emergence of 26 amino acid mutations and two deletions, 57% of them in the Spike protein. Such a combination of mutations has never been observed in other SARS-CoV-2 lineages detected so far.

CONCLUSION:

Our data confirm that persistent infection in certain immunocompromised individuals for a long time may favor the dangerous emergence of new SARS-CoV-2 variants with immune evasion properties.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Variants Limits: Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Variants Limits: Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article