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Comparative pharmacokinetics of 24 major bioactive components in normal and ARDS rats after oral administration of Xuanfei Baidu granules.
Wang, Xinrui; Zhang, Jingze; Luo, Lifei; Song, Xinbo; Wang, Ping; Liu, Dailin.
  • Wang X; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Tianjin Modern Innovation Chinese Medicine Technology Co., Ltd., Tianjin, China.
  • Zhang J; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Tianjin Modern Innovation Chinese Medicine Technology Co., Ltd., Tianjin, China.
  • Luo L; Tianjin Modern Innovation Chinese Medicine Technology Co., Ltd., Tianjin, China.
  • Song X; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Wang P; Tianjin Modern Innovation Chinese Medicine Technology Co., Ltd., Tianjin, China.
  • Liu D; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Tianjin Modern Innovation Chinese Medicine Technology Co., Ltd., Tianjin, China. Electronic address: dailinlch@163.com.
J Ethnopharmacol ; 296: 115472, 2022 Oct 05.
Article in English | MEDLINE | ID: covidwho-1895183
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE Xuanfei Baidu prescription, consisting of 13 Chinese medicines, was formulated by academicians Boli Zhang and Professor Qingquan Liu based on their experience in first-line clinical treatment of COVID-19. Xuanfei Baidu granules (XFBD granules) are a proprietary Chinese medicine preparation developed based on Xuanfei Baidu prescription. It is recommended for the treatment of patients with the common wet toxin and lung stagnation syndrome of COVID-19. However, the pharmacokinetic characteristics of its major bioactive components in rats under different physiological and pathological conditions are unclear. MATERIALS AND

METHODS:

A rapid and sensitive analytical method, ultra-performance liquid chromatography coupled with mass spectrometry (UPLC-MS/MS), was developed and applied to 24 major bioactive components in normal and ARDS rats after oral administration of XFBD granules. We studied the metabolic process of XFBD granules in vivo to compare the differences in pharmacokinetic parameters between normal and model metabolic processes.

RESULTS:

This method was successfully applied to the pharmacokinetic investigation of 24 major components of XFBD granules following oral administration in normal and ARDS rats. Eight components, including ephedrine and amygdalin, were more highly absorbed and had shorter Tmax values than the model group; the absorption of six components, such as rhein, decreased in ARDS rats, and there was no significant difference in the absorption of ten components, such as verbenalin and naringin, between the normal and ARDS rats. The results showed that the peak times of other analytes were very short, and 80% of these target constituents were eliminated in both normal and ARDS rats within 6 h except for liquiritigenin and 18ß-glycyrrhetinic acid.

CONCLUSIONS:

In this study, a rapid and sensitive UPLC-MS/MS analytical method was developed and applied to 24 major bioactive components in normal and ARDS rats after the oral administration of XFBD granules. This will serve to form the basis for further studies on the pharmacokinetic-pharmacodynamic correlation of XFBD granules.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Drugs, Chinese Herbal / COVID-19 Type of study: Prognostic study Topics: Traditional medicine Limits: Animals Language: English Journal: J Ethnopharmacol Year: 2022 Document Type: Article Affiliation country: J.jep.2022.115472

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Drugs, Chinese Herbal / COVID-19 Type of study: Prognostic study Topics: Traditional medicine Limits: Animals Language: English Journal: J Ethnopharmacol Year: 2022 Document Type: Article Affiliation country: J.jep.2022.115472