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Genosensors as an alternative diagnostic sensing approaches for specific detection of virus species: A review of common techniques and outcomes.
Babaei, Abouzar; Pouremamali, Amir; Rafiee, Nastaran; Sohrabi, Hessamaddin; Mokhtarzadeh, Ahad; de la Guardia, Miguel.
  • Babaei A; Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
  • Pouremamali A; Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
  • Rafiee N; Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
  • Sohrabi H; Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.
  • Mokhtarzadeh A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • de la Guardia M; Department of Analytical Chemistry, University of Valencia, Dr. Moliner 50, 46100, Burjassot, Valencia, Spain.
Trends Analyt Chem ; 155: 116686, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-1895467
ABSTRACT
Viral infections are responsible for the deaths of millions of people throughout the world. Since outbreak of highly contagious and mutant viruses such as contemporary sars-cov-2 pandemic, has challenged the conventional diagnostic methods, the entity of a thoroughly sensitive, specific, rapid and inexpensive detecting technique with minimum level of false-positivity or -negativity, is desperately needed more than any time in the past decades. Biosensors as minimized devices could detect viruses in simple formats. So far, various nucleic acid, immune- and protein-based biosensors were designed and tested for recognizing the genome, antigen, or protein level of viruses, respectively; however, nucleic acid-based sensing techniques, which is the foundation of constructing genosensors, are preferred not only because of their ultra-sensitivity and applicability in the early stages of infections but also for their ability to differentiate various strains of the same virus. To date, the review articles related to genosensors are just confined to particular pathogenic diseases; In this regard, the present review covers comprehensive information of the research progress of the electrochemical, optical, and surface plasmon resonance (SPR) genosensors that applied for human viruses' diseases detection and also provides a well description of viruses' clinical importance, the conventional diagnosis approaches of viruses and their disadvantages. This review would address the limitations in the current developments as well as the future challenges involved in the successful construction of sensing approaches with the functionalized nanomaterials and also allow exploring into core-research works regarding this area.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study Language: English Journal: Trends Analyt Chem Year: 2022 Document Type: Article Affiliation country: J.trac.2022.116686

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study Language: English Journal: Trends Analyt Chem Year: 2022 Document Type: Article Affiliation country: J.trac.2022.116686