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COVID19 vaccination in adults with sickle cell disease is not associated with increases in rates of pain crisis.
Friedman, Elana; Minniti, Caterina; Campbell, Sean; Curtis, Susanna.
  • Friedman E; Albert Einstein College of Medicine, Bronx, NY, USA.
  • Minniti C; Montefiore Medical Center, Bronx, NY, USA.
  • Campbell S; Montefiore Medical Center, Bronx, NY, USA.
  • Curtis S; Montefiore Medical Center, Bronx, NY, USA.
Hematology ; 27(1): 742-744, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-1895708
ABSTRACT
ABSTRACTPeople with sickle cell disease (SCD) are more vulnerable to hospitalization, pneumonia, and pain following COVID-19 infection. However, given the association between the inflammatory response and vaso-occlusive crises in SCD and a case report of vaso-occlusive crises following administration of the ChAdOx1 nCov-195-7/AstraZeneca vaccine, there is concern that the administration of COVID-19 vaccines in people with SCD might provoke a vaso-occlusive crisis. To address this critical gap in knowledge, we sought to examine acute care usage for vaso-occlusive crisis and frequency and severity of side effects following COVID-19 vaccination among patients at the Montefiore Sickle Cell Center for Adults. As part of regular care, patients were asked if they had received COVID-19 vaccination and any side effects were noted. Electronic medical records were reviewed for the type of vaccine, dates received, episodes of vaso-occlusive crises within seven days of a dose, and side effects noted. The risk of average hospital utilization per week in 2019 was calculated as a baseline. We found that fewer than 1 in 10 patients presented to the hospital within seven days of vaccination and that the risk of hospital utilization was similar to the average risk in a week in 2019. Of patients who reported side effects, one reported a possible case of sensorineural hearing loss otherwise no other rare side effects, including thrombosis or death, were reported.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pain / COVID-19 Vaccines / COVID-19 / Anemia, Sickle Cell Type of study: Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Humans Language: English Journal: Hematology Journal subject: Hematology Year: 2022 Document Type: Article Affiliation country: 16078454.2022.2085072

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pain / COVID-19 Vaccines / COVID-19 / Anemia, Sickle Cell Type of study: Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Humans Language: English Journal: Hematology Journal subject: Hematology Year: 2022 Document Type: Article Affiliation country: 16078454.2022.2085072