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T Lymphocytes as Targets for SARS-CoV-2.
Kuklina, Elena M.
  • Kuklina EM; Perm Federal Research Center, Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, 614081, Russia. ibis_07@mail.ru.
Biochemistry (Mosc) ; 87(6): 566-576, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1896044
ABSTRACT
Despite numerous data on the absence or weak expression of the main functional receptor of SARS-CoV-2 angiotensin-converting enzyme 2 (ACE2) by T cells, it was recently demonstrated that the new coronavirus can efficiently infect T lymphocytes. Here, we analyze the data on the alternative (ACE2-independent) pathways of cell infection, identified T cell subpopulations that serve as the most plausible targets of SARS-CoV-2, discuss the mechanisms of virus-cell interaction, including both infectious and non-infectious pathways of T lymphocyte regulation, and estimate the role of the virus-dependent damage of T lymphocytes in COVID-19 pathogenesis. Particular attention is paid to regulatory T cells as potential targets of SARS-CoV-2, as well as to the possible involvement of exosomes in the sensitivity of peripheral T cells to the virus.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme 2 / COVID-19 Limits: Humans Language: English Journal: Biochemistry (Mosc) Year: 2022 Document Type: Article Affiliation country: S0006297922060086

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme 2 / COVID-19 Limits: Humans Language: English Journal: Biochemistry (Mosc) Year: 2022 Document Type: Article Affiliation country: S0006297922060086