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Effective Natural Killer Cell Degranulation Is an Essential Key in COVID-19 Evolution.
Garcinuño, Sara; Gil-Etayo, Francisco Javier; Mancebo, Esther; López-Nevado, Marta; Lalueza, Antonio; Díaz-Simón, Raquel; Pleguezuelo, Daniel Enrique; Serrano, Manuel; Cabrera-Marante, Oscar; Allende, Luis M; Paz-Artal, Estela; Serrano, Antonio.
  • Garcinuño S; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
  • Gil-Etayo FJ; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
  • Mancebo E; Department of Immunology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
  • López-Nevado M; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
  • Lalueza A; Department of Immunology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
  • Díaz-Simón R; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
  • Pleguezuelo DE; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
  • Serrano M; Department of Internal Medicine, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
  • Cabrera-Marante O; Department of Internal Medicine, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
  • Allende LM; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
  • Paz-Artal E; Department of Immunology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
  • Serrano A; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
Int J Mol Sci ; 23(12)2022 Jun 13.
Article in English | MEDLINE | ID: covidwho-1896884
ABSTRACT
NK degranulation plays an important role in the cytotoxic activity of innate immunity in the clearance of intracellular infections and is an important factor in the outcome of the disease. This work has studied NK degranulation and innate immunological profiles and functionalities in COVID-19 patients and its association with the severity of the disease. A prospective observational study with 99 COVID-19 patients was conducted. Patients were grouped according to hospital requirements and severity. Innate immune cell subpopulations and functionalities were analyzed. The profile and functionality of innate immune cells differ between healthy controls and severe patients; CD56dim NK cells increased and MAIT cells and NK degranulation rates decreased in the COVID-19 subjects. Higher degranulation rates were observed in the non-severe patients and in the healthy controls compared to the severe patients. Benign forms of the disease had a higher granzymeA/granzymeB ratio than complex forms. In a multivariate analysis, the degranulation capacity resulted in a protective factor against severe forms of the disease (OR 0.86), whereas the permanent expression of NKG2D in NKT cells was an independent risk factor (OR 3.81; AUC 0.84). In conclusion, a prompt and efficient degranulation functionality in the early stages of infection could be used as a tool to identify patients who will have a better evolution.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Natural Killer T-Cells / COVID-19 Type of study: Etiology study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23126577

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Natural Killer T-Cells / COVID-19 Type of study: Etiology study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23126577