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Risk of SARS-CoV-2 Reinfections in a Prospective Inception Cohort Study: Impact of COVID-19 Vaccination.
Casado, José L; Haemmerle, Johannes; Vizcarra, Pilar; Ramirez-Alonso, Gema; Salazar-Tosco, Andrea; Romero-Hernandez, Beatriz; Blasco, Magdalena; Rodriguez-Dominguez, Mario; Mirabella, Itria G; Vallejo, Alejandro; Fernandez-Escribano, Marina.
  • Casado JL; Department of Infectious Diseases, IRYCIS (Instituto Ramon y Cajal para la Investigación Sanitaria), Hospital Universitario Ramón y Cajal, Ctra Colmenar Km 9, 28034 Madrid, Spain.
  • Haemmerle J; Department of Occupational Safety and Health, University Hospital Ramón y Cajal, 28034 Madrid, Spain.
  • Vizcarra P; Department of Infectious Diseases, IRYCIS (Instituto Ramon y Cajal para la Investigación Sanitaria), Hospital Universitario Ramón y Cajal, Ctra Colmenar Km 9, 28034 Madrid, Spain.
  • Ramirez-Alonso G; Department of Occupational Safety and Health, University Hospital Ramón y Cajal, 28034 Madrid, Spain.
  • Salazar-Tosco A; Department of Occupational Safety and Health, University Hospital Ramón y Cajal, 28034 Madrid, Spain.
  • Romero-Hernandez B; Department of Microbiology, Centro de Investigación Biomédica en Red en Epidemiologia y Salud Pública, CIBERESP, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
  • Blasco M; Department of Occupational Safety and Health, University Hospital Ramón y Cajal, 28034 Madrid, Spain.
  • Rodriguez-Dominguez M; Department of Microbiology, Centro de Investigación Biomédica en Red en Epidemiologia y Salud Pública, CIBERESP, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain.
  • Mirabella IG; Department of Occupational Safety and Health, University Hospital Ramón y Cajal, 28034 Madrid, Spain.
  • Vallejo A; Department of Infectious Diseases, IRYCIS (Instituto Ramon y Cajal para la Investigación Sanitaria), Hospital Universitario Ramón y Cajal, Ctra Colmenar Km 9, 28034 Madrid, Spain.
  • Fernandez-Escribano M; Laboratory of Immunovirology, Department of Infectious Diseases, IRYCIS (Instituto Ramon y Cajal para la Investigación Sanitaria), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
J Clin Med ; 11(12)2022 Jun 10.
Article in English | MEDLINE | ID: covidwho-1896889
ABSTRACT
The risk of reinfection could be related to the initial SARS-CoV-2 clinical presentation, but there are no data about the risk change after SARS-CoV-2 vaccination. We evaluated the rate of reinfection in an inception cohort study of 4943 health care workers (HCWs) according to symptoms and serologic results during March-May 2020. Incidence rates (IR) and IR ratios (IRR) before and after SARS-CoV-2 vaccination were determined by adjusting Poisson models. Overall, 1005 HCWs (20.3%) referred COVID-19 suggestive symptoms during the first surge of disease, and 33.5% and 55% presented a positive PCR or serology result, respectively. Meanwhile, 13% of asymptomatic HCWs had specific antibodies. During a follow up of 3422.2 person-years before vaccination, the rate of reinfection among seropositive individuals was 81% lower for those who were symptomatic compared with those who were asymptomatic (IRR of 0.19; 95% CI, 0.05-0.67; p = 0.003). During the 3100 person-years period after vaccination, an overall 74% decrease in the rate of infection was observed (IRR of 0.26; 95% CI, 0.21-0.32; p < 0.001), with a significant 83% and 70% decrease in seropositive and seronegative HCWs, respectively. In conclusion, the risk of SARS-CoV-2 reinfections is closely related to the clinical and serological presentation of COVID-19. COVID-19 vaccination further decreases the risk of reinfection more markedly among seropositive.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11123352

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11123352