Serum Ferritin Levels for the Prediction of Mortality among COVID-19 Patients in an Indonesia’s National Referral Hospital
Open Access Macedonian Journal of Medical Sciences
; 10:1056-1061, 2022.
Article
in English
| EMBASE | ID: covidwho-1896942
ABSTRACT
BACKGROUND:
Early identification of clinical outcomes is necessary for risk classification in COVID-19 patients. This study help in evaluating the progression of the disease and the patient’s therapy.AIM:
This study aims to determine serum ferritin levels for the prediction of mortality among COVID-19 patients in an Indonesia’s National Referral Hospital.METHODS:
A retrospective cohort study was conducted on 142 confirmed positive COVID-19 patients between March 2020 until March 2021 at Dr. M. Djamil General Hospital as a National Referral Hospital in Indonesia. Data obtained from medical record documents and examination of ferritin levels was carried out at the beginning of treatment. The Chi-square test and survival analysis with the log-rank test and Kaplan–Meier methods were used to analyze the data. The SPSS version 15 was used to analyze the data.RESULTS:
The serum ferritin cutoff point for COVID-19 patients that can be used to predict poor outcomes was >651.02 ng/mL with sensitivity 79.3%, specificity 80.5%, and accuracy 85.0%. Age, comorbid diabetes mellitus, number of comorbidities, symptoms of trouble breathing, oxygen saturation, severity, and mortality outcome were all associated to ferritin levels >651.02 ng/mL. The Kaplan–Meier curve showed that ferritin levels >651.02 ng/mL were associated for risk of poor outcome COVID-19 patients (HR = 8.84, [95% CI 3.59–21.73]).CONCLUSION:
The ferritin cutoff point for predicting poor prognosis in COVID-19 patients was 651.02 ng/mL. However, ferritin serum levels cannot be used as a single predictor in determining the poor outcome of COVID-19.
adult; article; breathing; cohort analysis; comorbidity; controlled study; coronavirus disease 2019; data analysis software; diabetes mellitus; female; ferritin blood level; gene expression; general hospital; human; human tissue; Indonesia; Kaplan Meier method; log rank test; major clinical study; male; medical record; mortality; outcome assessment; oxygen saturation; patient referral; prediction; prognosis; retrospective study; sensitivity and specificity; survival analysis; endogenous compound; ferritin
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
English
Journal:
Open Access Macedonian Journal of Medical Sciences
Year:
2022
Document Type:
Article
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