Research progress in anti-coronavirus effect and safety of chloroquine
Chinese Journal of Pharmacology and Toxicology
; 34(4):272-277, 2020.
Article
in Chinese
| CAB Abstracts | ID: covidwho-1897878
ABSTRACT
Coronavirus, identified as a zoonotic pathogen, can cause pulmonary infections and even a pandemic. Corona Virus Disease 2019 (COVID-19), which was induced by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), struck the world in December 2019. There is no specific drug for coronavirus. As a classical antimalarial drug, chloroquine has been proved to have antiviral activity by changing the pH of endocytosis, via autophagy reactions and by changing the glycosylation mode of the virus envelope. At the cellular level, chloroquine has inhibitory effects on SARS-CoV, Middle East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV- 2. Recent clinical research results are beginning to show that chloroquine can improve the success rate and prognosis. Chloroquine has been used less clinically in recent years due to the many adverse reactions it causes. The safety of chloroquine used in coronavirus infection requires in-depth evaluation. This article summarizes research progress in the anti-coronavirus effect and safety of chloroquine in order to provide reference for its clinical application.
Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Pesticides and Drugs; Control [HH405]; Pharmacology [VV730]; antimalarials; antiviral agents; antiviral properties; chloroquine; coronavirus disease 2019; endocytosis; glycosylation; human diseases; lungs; Middle East respiratory syndrome; pandemics; prognosis; respiratory diseases; reviews; safety; viral diseases; zoonoses; severe acute respiratory syndrome; man; Middle East respiratory syndrome coronavirus; Severe acute respiratory syndrome coronavirus 2; Severe acute respiratory syndrome coronavirus; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Severe acute respiratory syndrome-related coronavirus; antivirals; anti-viral properties; MERS-CoV; lung diseases; SARS-CoV-2; viral infections; zoonotic infections; SARS
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Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Experimental Studies
Language:
Chinese
Journal:
Chinese Journal of Pharmacology and Toxicology
Year:
2020
Document Type:
Article
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