Effects of SARS-CoV-2 virus on thyroid function: a narrative review
Iranian Journal of Endocrinology and Metabolism
; 23(3), 2021.
Article
in Persian
| CAB Abstracts | ID: covidwho-1897985
ABSTRACT
SARS-CoV-2 is a type of coronavirus that causes COVID-19 disease. The virus can infect various organs by triggering hormones, regulatory and messenger molecules, and immune-inflammatory responses. Given the vital role of thyroid in metabolism, it is important to understand the potential effects of SARS-CoV-2 on the thyroid gland. In this article, reports and studies examining the effects of SARS-CoV-2 infection on thyroid are reviewed, and possible effects of this virus on thyroid function are discussed. According to the available evidence, SARS-CoV-2 can adversely impact thyroid function directly by affecting the pituitary-thyroid axis or indirectly by triggering immune-inflammatory responses. COVID-19-dependent thyroid disorders have been biochemically observed in three forms hypothyroidism, thyrotoxicosis, and nonthyroidal illness syndrome. Subacute thyroiditis has been one of the most common clinical conditions of SARS-CoV-2-dependent thyrotoxicosis. In addition, SARS-CoV-2 may cause recurrence of improved thyroid diseases or exacerbate current diseases. There is no evidence that thyroid disease, including thyroid cancer, increases the risk of COVID-19 or exacerbates its complications. According to current studies, COVID-19 medications, including glucocorticoids and anticoagulants, have no adverse effects on thyroid function in non-acute COVID-19 patients. Further studies are needed to investigate the interactions between SARS-CoV-2 infection and thyroid function.
Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Human Immunology and Allergology [VV055]; Non-communicable Human Diseases and Injuries [VV600]; viral diseases; thyroid gland; thyroid function; thyroid diseases; thyroid cancer; reviews; pituitary; pandemics; inflammation; immune response; human diseases; glucocorticoids; drug therapy; coronavirus disease 2019; anticoagulants; viruses; Severe acute respiratory syndrome coronavirus 2; man; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; viral infections; thyroid; cancers; SARS-CoV-2; hypophysis; pituitary gland; immunity reactions; immunological reactions; chemotherapy
Search on Google
Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Experimental Studies
/
Reviews
Language:
Persian
Journal:
Iranian Journal of Endocrinology and Metabolism
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS