Reactivation of hepatitis B in patients recovering from COVID-19
Vestnik KAZNMU
; 3:149-153, 2021.
Article
in Russian
| GIM | ID: covidwho-1898228
ABSTRACT
The pandemic of the new coronavirus infection caused by the SARS-CoV-2 virus is a challenge to the health system around the world. At the moment, we have more information about this disease, which is manifested mainly by symptoms of a respiratory infection, from mild manifestations of ARVI to severe lung damage. Also, coronavirus infection often manifests itself as symptoms of a gastrointestinal disease, in the form of vomiting, diarrhea and abdominal pain. In addition, over a year of observation, starting from the very beginning of the pandemic in China, liver dysfunctions of various origins have been described in patients with coronavirus infection. Possible reasons include the direct cytopathic effect of the virus capable of binding to ACE2beta receptors of the hepato-biliary system, immune-mediated damage to hepatocytes, including during a "cytokine storm" and hepatotoxicity of drugs used in coronavirus infection. In addition to these mechanisms of liver damage, there is also a reactivation of chronic persistent infections. In particular, we are talking about the reactivation of chronic hepatitis B. In addition to the burden of infection in the manifest period, there are no less severe consequences for convalescents or those who have suffered a mild illness, which we must remember in order to take the necessary measures in the near and distant period of recovery after COVID -19. In this article, we present our own observations of the reactivation of chronic hepatitis in 4 patients who underwent manifest COVID-19.
case reports; chronic infections; clinical aspects; concurrent infections; coronavirus disease 2019; cytokines; cytopathogenicity; hepatitis B; human diseases; liver; lungs; pandemics; symptoms; viral diseases; viral hepatitis; Hepatitis B virus; man; Severe acute respiratory syndrome coronavirus 2; China; APEC countries; East Asia; Asia; high Human Development Index countries; upper-middle income countries; Orthohepadnavirus; Hepadnaviridae; DNA Reverse Transcribing Viruses; viruses; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; People's Republic of China; clinical picture; SARS-CoV-2; viral infections
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Collection:
Databases of international organizations
Database:
GIM
Language:
Russian
Journal:
Vestnik KAZNMU
Year:
2021
Document Type:
Article
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