Simulating the impact of vaccination rates on the initial stages of a COVID-19 outbreak in Aotearoa New Zealand with a stochastic model.

ABSTRACT

AIM: The August 2021 COVID-19 outbreak in Auckland caused the New Zealand Government to transition from an elimination strategy to suppression, which relies heavily on high vaccination rates in the population. As restrictions ease and as COVID-19 spreads throughout New Zealand, there is a need to understand how different levels of vaccination will impact the initial stages of COVID-19 outbreaks that are seeded around the country. METHOD: A stochastic branching process model is used to simulate the initial spread of a COVID-19 outbreak for different vaccination rates. RESULTS: High vaccination rates are effective at minimising the number of infections and hospitalisations. Increasing vaccination rates from 20% (approximate value at the start of the August 2021 outbreak) to 80% (approximate proposed target) of the total population can reduce the median number of infections that occur within the first four weeks of an outbreak from 1011 to 14 (25th and 75th quantiles of 545-1602 and 2-32 for V=20% and V=80%, respectively). As the vaccination rate increases, the number of breakthrough infections (infections in fully vaccinated individuals) and hospitalisations of vaccinated individuals increases. Unvaccinated individuals, however, are 3.3x more likely to be infected with COVID-19 and 25x more likely to be hospitalised. CONCLUSION: This work demonstrates the importance of vaccination in protecting individuals from COVID-19, preventing high caseloads, and minimising the number of hospitalisations and hence limiting the pressure on the healthcare system.