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A closer look at endothelial injury-induced platelet hyperactivity and the use of aspirin in the treatment of COVID infection.
Lichtenberger, Lenard M; Szabo, Sandor.
  • Lichtenberger LM; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, USA. lenard.m.lichtenberger@uth.tmc.edu.
  • Szabo S; American University of Health Sciences, Signal Hill/Long Beach, CA, USA. lenard.m.lichtenberger@uth.tmc.edu.
Inflammopharmacology ; 30(4): 1475-1476, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1899225
ABSTRACT
In this commentary, we make a case that the mechanism of COVID pathogenesis is related to virus-induced endothelial injury resulting in platelet activation and the formation of microthrombi both systemically and in cardiac and pulmnonary circulation which result in major causes of COVID morbidity and mortality. Aspirin by virtue of its irreversible inhibition of platelet COX-1, should reverse these platelet-induced pathogenic changes associated with COVID infection for the 6-9 day lifetime of the platelet. We also cite recent findings of a retrospective analysis that supports the use of low-dose (81 mg) aspirin to treat the symptoms associated with the early stages of COVID infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Aspirin / COVID-19 Drug Treatment Type of study: Observational study Limits: Humans Language: English Journal: Inflammopharmacology Journal subject: Pharmacology / Drug Therapy Year: 2022 Document Type: Article Affiliation country: S10787-022-01015-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Aspirin / COVID-19 Drug Treatment Type of study: Observational study Limits: Humans Language: English Journal: Inflammopharmacology Journal subject: Pharmacology / Drug Therapy Year: 2022 Document Type: Article Affiliation country: S10787-022-01015-w