Autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination: case report and literature review.
Clin J Gastroenterol
; 15(4): 791-795, 2022 Aug.
Article
in English
| MEDLINE | ID: covidwho-1899346
ABSTRACT
Although vaccines have been effective against the worldwide pandemic of Coronavirus Disease 19 (COVID-19), some case reports have described autoimmune hepatitis triggered by COVID-19 vaccination. Meanwhile, hepatitis C virus (HCV) is known to be related to autoimmune diseases. Here, we report a case of autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination. An 82-year-old woman was referred to our hospital for severe liver injury. She had received a COVID-19 vaccination 7 days prior. She had a history of HCV treatment with direct-acting antivirals 7 years previously. In her blood data, despite HCV antibody positivity, she was negative for HCV RNA by real-time RT-PCR. Anti-nuclear antibody was positive and IgG was elevated. Interface hepatitis and plasma cell infiltration were confirmed pathologically. She was diagnosed as autoimmune hepatitis and her liver injury quickly improved after initiation of steroid administration. This is a first case report of autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Hepatitis C, Chronic
/
Hepatitis, Autoimmune
/
COVID-19 Vaccines
/
COVID-19
Type of study:
Case report
/
Observational study
/
Prognostic study
/
Reviews
Topics:
Vaccines
Limits:
Female
/
Humans
Language:
English
Journal:
Clin J Gastroenterol
Year:
2022
Document Type:
Article
Affiliation country:
S12328-022-01654-0
Similar
MEDLINE
...
LILACS
LIS