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Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Liao, Mingfeng; Liu, Yang; Yuan, Jing; Wen, Yanling; Xu, Gang; Zhao, Juanjuan; Cheng, Lin; Li, Jinxiu; Wang, Xin; Wang, Fuxiang; Liu, Lei; Amit, Ido; Zhang, Shuye; Zhang, Zheng.
  • Liao M; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China.
  • Liu Y; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China.
  • Yuan J; Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, China.
  • Wen Y; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China.
  • Xu G; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China.
  • Zhao J; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China.
  • Cheng L; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China.
  • Li J; Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, China.
  • Wang X; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China.
  • Wang F; Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, China.
  • Liu L; Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China. liulei3322@aliyun.com.
  • Amit I; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China. liulei3322@aliyun.com.
  • Zhang S; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. ido.amit@weizmann.ac.il.
  • Zhang Z; Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. zhangshuye@shphc.org.cn.
Nat Med ; 26(6): 842-844, 2020 06.
Article in English | MEDLINE | ID: covidwho-1900503
ABSTRACT
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Single-Cell Analysis / Betacoronavirus Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Nat Med Journal subject: Molecular Biology / Medicine Year: 2020 Document Type: Article Affiliation country: S41591-020-0901-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Single-Cell Analysis / Betacoronavirus Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Nat Med Journal subject: Molecular Biology / Medicine Year: 2020 Document Type: Article Affiliation country: S41591-020-0901-9