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Metal-based strategies for the fight against COVID-19.
Li, Hongyan; Yuan, Shuofeng; Wei, Xueying; Sun, Hongzhe.
  • Li H; Department of Chemistry, State Key Laboratory of Synthetic Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. hsun@hku.hk.
  • Yuan S; Department of Microbiology and State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
  • Wei X; Department of Chemistry, State Key Laboratory of Synthetic Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. hsun@hku.hk.
  • Sun H; Department of Microbiology and State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Chem Commun (Camb) ; 58(54): 7466-7482, 2022 Jul 05.
Article in English | MEDLINE | ID: covidwho-1900677
ABSTRACT
The emerging COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has claimed over six million lives globally to date. Despite the availability of vaccines, the pandemic still cannot be fully controlled owing to rapid mutation of the virus that renders enhanced transmissibility and antibody evasion. This is thus an unmet need to develop safe and effective therapeutic options for COVID-19, in particular, remedies that can be used at home. Considering the great success of multi-targeted cocktail therapy for the treatment of viral infections, metal-based drugs might represent a unique and new source of antivirals that resemble a cocktail therapy in terms of their mode of actions. In this review, we first summarize the role that metal ions played in SARS-CoV-2 viral replication and pathogenesis, then highlight the chemistry of metal-based strategies in the fight against SARS-CoV-2 infection, including both metal displacement and chelation based approaches. Finally, we outline a perspective and direction on how to design and develop metal-based antivirals for the fight against the current or future coronavirus pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Drug Treatment Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: D2cc01772e

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Drug Treatment Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: D2cc01772e