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Characterization of virologic rebound following nirmatrelvir-ritonavir treatment for COVID-19.
Boucau, Julie; Uddin, Rockib; Marino, Caitlin; Regan, James; Flynn, James P; Choudhary, Manish C; Chen, Geoffrey; Stuckwisch, Ashley M; Mathews, Josh; Liew, May Y; Singh, Arshdeep; Reynolds, Zahra; Iyer, Surabhi L; Chamberlin, Grace C; Vyas, Tammy D; Vyas, Jatin M; Turbett, Sarah E; Li, Jonathan Z; Lemieux, Jacob E; Barczak, Amy K; Siedner, Mark J.
  • Boucau J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Uddin R; Massachusetts General Hospital, Boston, MA, USA.
  • Marino C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Regan J; Brigham and Women's Hospital Boston, MA, USA.
  • Flynn JP; Brigham and Women's Hospital Boston, MA, USA.
  • Choudhary MC; Brigham and Women's Hospital Boston, MA, USA.
  • Chen G; Harvard Medical School, Boston, MA, USA.
  • Stuckwisch AM; Massachusetts General Hospital, Boston, MA, USA.
  • Mathews J; Massachusetts General Hospital, Boston, MA, USA.
  • Liew MY; Massachusetts General Hospital, Boston, MA, USA.
  • Singh A; Massachusetts General Hospital, Boston, MA, USA.
  • Reynolds Z; Massachusetts General Hospital, Boston, MA, USA.
  • Iyer SL; Massachusetts General Hospital, Boston, MA, USA.
  • Chamberlin GC; Massachusetts General Hospital, Boston, MA, USA.
  • Vyas TD; Massachusetts General Hospital, Boston, MA, USA.
  • Vyas JM; Massachusetts General Hospital, Boston, MA, USA.
  • Turbett SE; Massachusetts General Hospital, Boston, MA, USA.
  • Li JZ; Harvard Medical School, Boston, MA, USA.
  • Lemieux JE; Massachusetts General Hospital, Boston, MA, USA.
  • Barczak AK; Brigham and Women's Hospital Boston, MA, USA.
  • Siedner MJ; Harvard Medical School, Boston, MA, USA.
Clin Infect Dis ; 2022 Jun 23.
Article in English | MEDLINE | ID: covidwho-2228289
ABSTRACT
We enrolled seven individuals with recurrent symptoms or antigen test conversion following nirmatrelvir-ritonavir treatment. High viral loads (median 6.1 log10 copies/mL) were detected after rebound for a median of 17 days after initial diagnosis. Three had culturable virus for up to 16 days after initial diagnosis. No known resistance-associated mutations were identified.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid