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Time of Day of BNT162b2 COVID-19 Immunization Affects Total SARS-CoV-2 Antibody Levels but Not Neutralizing Activity.
Filippatos, Filippos; Tatsi, Elizabeth-Barbara; Efthymiou, Vasiliki; Syriopoulou, Vasiliki; Michos, Athanasios.
  • Filippatos F; First Department of Pediatrics, Infectious Diseases and Chemotherapy Research Laboratory, Medical School, National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, Athens, Greece.
  • Tatsi EB; University Research Institute of Maternal and Child Health and Precision Medicine, Athens, Greece.
  • Efthymiou V; University Research Institute of Maternal and Child Health and Precision Medicine, Athens, Greece.
  • Syriopoulou V; First Department of Pediatrics, Infectious Diseases and Chemotherapy Research Laboratory, Medical School, National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, Athens, Greece.
  • Michos A; First Department of Pediatrics, Infectious Diseases and Chemotherapy Research Laboratory, Medical School, National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, Athens, Greece.
J Biol Rhythms ; 37(5): 562-566, 2022 10.
Article in English | MEDLINE | ID: covidwho-1902252
ABSTRACT
To examine whether immunization time affects the immune responses elicited by the BNT162b2 COVID-19 vaccine, we investigated the possible association between total SARS-CoV-2 spike protein receptor binding domain (TAbs-RBD) and neutralizing (NAbs-RBD) antibodies with vaccination time. A cohort of 468 healthcare workers (mean age [±SD] 48 [±13] years), were included in the study. One month after the second dose, healthcare workers who were vaccinated between 1500-2200 h had higher TAbs-RBD compared to 0700-1100 h and 1100-1500 h (p = 0.006). One month after the third dose, healthcare workers who were vaccinated between 0700-1100 h and 1500-2200 h had significantly higher TAbs-RBD compared to 1100-1500 h (p = 0.034). However, no association of NAbs-RBD with vaccination time was detected after each of the 3 doses (p > 0.4). Despite the possible effect of BNT162b2 vaccination time in TAbs-RBD levels, possibly due to rhythmic expression of clock genes, neutralizing activity was not associated with vaccination time and, therefore, further investigation is required.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Circadian Rhythm / COVID-19 / BNT162 Vaccine / Antibodies, Viral Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Animals / Humans / Middle aged Language: English Journal: J Biol Rhythms Journal subject: Physiology Year: 2022 Document Type: Article Affiliation country: 07487304221100951

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Circadian Rhythm / COVID-19 / BNT162 Vaccine / Antibodies, Viral Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Animals / Humans / Middle aged Language: English Journal: J Biol Rhythms Journal subject: Physiology Year: 2022 Document Type: Article Affiliation country: 07487304221100951