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Impact of proton pump inhibitors on the in-hospital outcome of COVID-19 patients: a retrospective study.
Yao, Haijuan; Li, Hongyu; Ma, Zhuang; Wu, Yanyan; Tang, Yufu; Meng, Hao; Yu, Hao; Peng, Chengfei; Teng, Yue; Zhang, Quanyu; Zhu, Tianyi; Zhao, Haitao; Chu, Guiyang; Tong, Zhenhua; Liu, Lu; Lu, Hui; Qi, Xingshun.
  • Yao H; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Li H; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Ma Z; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Wu Y; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Tang Y; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Meng H; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Yu H; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Peng C; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Teng Y; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Zhang Q; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Zhu T; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Zhao H; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Chu G; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Tong Z; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang, P.R. China.
  • Liu L; COVID-19 Study Group, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenyang, Liaoning Province 110840, P.R. China.
  • Lu H; COVID-19 Study Group, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenyang, Liaoning Province 110840, P.R. China.
  • Qi X; COVID-19 Study Group, General Hospital of Northern Theater Command, Shenyang 110840, P.R. China.
Therap Adv Gastroenterol ; 15: 17562848221104365, 2022.
Article in English | MEDLINE | ID: covidwho-1902321
ABSTRACT

Background:

Coronavirus disease 2019 (COVID-19) has triggered a global public health crisis. Proton pump inhibitors (PPIs) are one of the most commonly prescribed drugs. However, the effect of PPIs on the clinical outcomes of COVID-19 patients remains unclear.

Methods:

All COVID-19 patients admitted to the Wuhan Huoshenshan Hospital from February 2020 to April 2020 were retrospectively collected. Patients were divided into PPIs and non-PPIs groups. Logistic regression analyses were performed to explore the effects of PPIs on the outcomes of COVID-19 patients, including transfer to intensive care unit, mechanical ventilation, and death. Subgroup analyses were performed according to the presence of upper gastrointestinal symptoms potentially associated with acid and the routes, types, median total dosage, and duration of PPIs. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.

Results:

Of the 3024 COVID-19 patients included, 694 and 2330 were in PPIs and non-PPIs groups, respectively. Univariate logistic regression analysis showed that PPIs significantly increased the risk of reaching the composite endpoint in COVID-19 patients (OR = 10.23, 95% CI = 6.90-15.16, p < 0.001). After adjusting for age, sex, comorbidities, other medications, and severe/critical COVID-19, PPIs were independently associated with an increased risk of reaching the composite endpoint (OR = 7.00, 95% CI = 4.57-10.71, p < 0.001). This association remained significant in patients with upper gastrointestinal symptoms and those who received an intravenous omeprazole alone, but not those who received oral lansoprazole or rabeprazole alone. It was not influenced by dosage or duration of PPIs.

Conclusion:

The use of intravenous PPIs alone during hospitalization may be associated with worse clinical outcome in COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Therap Adv Gastroenterol Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Therap Adv Gastroenterol Year: 2022 Document Type: Article