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Case Report: Immune Checkpoint Blockade Plus Interferon-Γ Add-On Antifungal Therapy in the Treatment of Refractory Covid-Associated Pulmonary Aspergillosis and Cerebral Mucormycosis.
Serris, Alexandra; Ouedrani, Amani; Uhel, Fabrice; Gazzano, Marianne; Bedarida, Vincent; Rouzaud, Claire; Bougnoux, Marie-Elisabeth; Raphalen, Jean-Herlé; Poirée, Sylvain; Lambotte, Olivier; Martin-Blondel, Guillaume; Lanternier, Fanny.
  • Serris A; Centre for Infectious Diseases and Tropical Medicine, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique -Hôpitaux de Paris, Université de Paris, Paris, France.
  • Ouedrani A; Immunology Laboratory, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique -Hôpitaux de Paris, Université de Paris, Paris, France.
  • Uhel F; Immunoregulation and Immunopathology, Département Immunologie UMR_S1151 UMR8253 Institut Necker Enfants Malades, Université de Paris, Paris, France.
  • Gazzano M; Intensive Care Medicine, Hôpital Louis Mourier, Assistance Publique -Hôpitaux de Paris, Colombes, France.
  • Bedarida V; Department of Immunologie, Hôpitaux universitaires Pitié Salpêtrière-Charles Foix, Assistance Publique -Hôpitaux de Paris, Paris, France.
  • Rouzaud C; Otolaryngology-Head and Neck Surgery Department, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Bougnoux ME; Centre for Infectious Diseases and Tropical Medicine, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique -Hôpitaux de Paris, Université de Paris, Paris, France.
  • Raphalen JH; Parasitology-Mycology Laboratory, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique -Hôpitaux de Paris, Paris, France.
  • Poirée S; Intensive Care Medicine, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique -Hôpitaux de Paris, Université de Paris, Paris, France.
  • Lambotte O; Department of Adult radiology, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique -Hôpitaux de Paris, Paris, France.
  • Martin-Blondel G; Service de Médecine Interne Immunologie Clinique, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, Le Kremlin Bicêtre, France.
  • Lanternier F; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IDMIT/IMVA-HB), UMR1184, Université Paris-Saclay, Inserm, CEA, Le Kremlin Bicêtre, France.
Front Immunol ; 13: 900522, 2022.
Article in English | MEDLINE | ID: covidwho-1903024
ABSTRACT
Invasive fungal diseases (IFD) still cause substantial morbidity and mortality, and new therapeutic approaches are urgently needed. Recent data suggest a benefit of checkpoint inhibitors (ICI). We report the case of a diabetic patient with refractory IFD following a SARSCoV-2 infection treated by ICI and interferon-gamma associated with antifungal treatment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Aspergillosis / COVID-19 / COVID-19 Drug Treatment / Mucormycosis Type of study: Case report / Observational study Topics: Long Covid Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.900522

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Aspergillosis / COVID-19 / COVID-19 Drug Treatment / Mucormycosis Type of study: Case report / Observational study Topics: Long Covid Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.900522