The Fate of Intranasally Instilled Silver Nanoarchitectures.
Nano Lett
; 22(13): 5269-5276, 2022 07 13.
Article
in English
| MEDLINE | ID: covidwho-1905595
ABSTRACT
The intranasal administration of drugs allows an effective and noninvasive therapeutic action on the respiratory tract. In an era of rapidly increasing antimicrobial resistance, new approaches to the treatment of communicable diseases, especially lung infections, are urgently needed. Metal nanoparticles are recognized as a potential last-line defense, but limited data on the biosafety and nano/biointeractions preclude their use. Here, we quantitatively and qualitatively assess the fate and the potential risks associated with the exposure to a silver nanomaterial model (i.e., silver ultrasmall-in-nano architectures, AgNAs) after a single dose instillation. Our results highlight that the biodistribution profile and the nano/biointeractions are critically influenced by both the design of the nanomaterial and the chemical nature of the metal. Overall, our data suggest that the instillation of rationally engineered nanomaterials might be exploited to develop future treatments for (non)communicable diseases of the respiratory tract.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Nanostructures
/
Metal Nanoparticles
Type of study:
Prognostic study
/
Qualitative research
Topics:
Vaccines
Language:
English
Journal:
Nano Lett
Year:
2022
Document Type:
Article
Affiliation country:
Acs.nanolett.2c01180
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