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Indeterminate pediatric acute liver failure: Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022.
Lexmond, Willem S; de Meijer, Vincent E; Scheenstra, René; Bontemps, Sander T H; Duiker, Evelien W; Schölvinck, Elisabeth H; Zhou, Xuewei; von Eije, Karin J; Reyntjens, Koen M E M; Verkade, Henkjan J; Porte, Robert J; de Kleine, Ruben H.
  • Lexmond WS; Department of Pediatrics, Section of Pediatric Gastroenterology and Hepatology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • de Meijer VE; Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Scheenstra R; Department of Pediatrics, Section of Pediatric Gastroenterology and Hepatology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Bontemps STH; Department of Pediatric Intensive Care, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Duiker EW; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Schölvinck EH; Department of Pediatric Infectious Diseases / Immunology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Zhou X; Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • von Eije KJ; Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Reyntjens KMEM; Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Verkade HJ; Department of Pediatrics, Section of Pediatric Gastroenterology and Hepatology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Porte RJ; Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • de Kleine RH; Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
United European Gastroenterol J ; 10(8): 795-804, 2022 10.
Article in English | MEDLINE | ID: covidwho-1905952
ABSTRACT
There is increasing global concern of severe acute hepatitis of unknown etiology in young children. In early 2022, our center for liver transplantation in the Netherlands treated five children who presented in short succession with indeterminate acute liver failure. Four children underwent liver transplantation, one spontaneously recovered. Here we delineate the clinical course and comprehensive diagnostic workup of these patients. Three of five patients showed a gradual decline of liver synthetic function and had mild neurological symptoms. Their clinical and histological findings were consistent with hepatitis. These three patients all had a past SARS-CoV-2 infection and two of them were positive for adenovirus DNA. The other two patients presented with advanced liver failure and encephalopathy and underwent dialysis as a bridge to transplantation. One of these children spontaneously recovered. We discuss this cluster of patients in the context of the currently elevated incidence of severe acute hepatitis in children.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Liver Failure, Acute / COVID-19 / Hepatitis Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Child / Child, preschool / Humans Country/Region as subject: Europa Language: English Journal: United European Gastroenterol J Year: 2022 Document Type: Article Affiliation country: Ueg2.12269

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Liver Failure, Acute / COVID-19 / Hepatitis Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Child / Child, preschool / Humans Country/Region as subject: Europa Language: English Journal: United European Gastroenterol J Year: 2022 Document Type: Article Affiliation country: Ueg2.12269