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Low risk of nosocomial severe acute respiratory syndrome-coronavirus-2 infection in patients with liver disease admitted to a hepatology unit at an academic hospital: A single-center experience.
Toniutto, Pierluigi; D'Aurizio, Federica; Cmet, Sara; Cussigh, Annarosa; Falleti, Edmondo; Fabris, Carlo; Sartor, Emma; Fornasiere, Ezio; Fumolo, Elisa; Bitetto, Davide; Curcio, Francesco.
  • Toniutto P; Hepatology and Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy. pierluigi.toniutto@uniud.it.
  • D'Aurizio F; Clinical Pathology, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
  • Cmet S; Clinical Pathology, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
  • Cussigh A; Clinical Pathology, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
  • Falleti E; Clinical Pathology, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
  • Fabris C; Hepatology and Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
  • Sartor E; Microbiology, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
  • Fornasiere E; Hepatology and Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
  • Fumolo E; Hepatology and Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
  • Bitetto D; Hepatology and Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
  • Curcio F; Clinical Pathology, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
Indian J Gastroenterol ; 41(3): 292-299, 2022 06.
Article in English | MEDLINE | ID: covidwho-1906551
ABSTRACT

BACKGROUND:

Patients with liver disease may be at increased risk of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection due to immune dysfunction. However, the risk of nosocomial SARS-CoV-2 infection in these patients remains unknown. This study aimed to determine whether patients with liver disease are at an increased risk of nosocomial transmission of SARS-CoV-2 infection upon admission to the hospital for diagnostic or therapeutic procedures.

METHODS:

The study prospectively enrolled 143 patients who were admitted at least once to the hepatology unit at our hospital; 95 patients (66%) were admitted at least twice during the study period. History of past symptomatic SARS-CoV-2 exposure was assessed on the day before hospital admission via an interview. Patients were evaluated for active SARS-CoV-2 infection via real-time reverse transcription-polymerase chain reaction (RT-PCR) performed on nasopharyngeal swabs and tests for serum anti-SARS-CoV-2 immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies.

RESULTS:

None of the patients enrolled tested positive for SARS-CoV-2 infection by RT-PCR at the first or the second clinical evaluation. One patient who had previously received a liver transplant and who had a history of symptomatic SARS-CoV-2 infection that occurred 4 months before hospital admission tested positive for anti-SARS-CoV-2 IgG but not IgM antibodies at each of the two hospital admissions.

CONCLUSIONS:

The results of our study suggest that patients with liver disease are at no increased risk of nosocomial SARS-CoV-2 infection. These data support the policy of maintaining clinical hospital checks that will be necessary until or possibly even after the completion of the current SARS-CoV-2 vaccination campaign.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cross Infection / Digestive System Diseases / Gastroenterology / COVID-19 / Liver Diseases Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Indian J Gastroenterol Journal subject: Gastroenterology Year: 2022 Document Type: Article Affiliation country: S12664-022-01241-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cross Infection / Digestive System Diseases / Gastroenterology / COVID-19 / Liver Diseases Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Indian J Gastroenterol Journal subject: Gastroenterology Year: 2022 Document Type: Article Affiliation country: S12664-022-01241-8