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High frequency of neutralizing antibodies to type I Interferon in HIV-1 patients hospitalized for COVID-19.
Scordio, Mirko; Frasca, Federica; Santinelli, Letizia; Sorrentino, Leonardo; Pierangeli, Alessandra; Turriziani, Ombretta; Mastroianni, Claudio M; Antonelli, Guido; Viscidi, Raphael P; d'Ettorre, Gabriella; Scagnolari, Carolina.
  • Scordio M; Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185 Rome, Italy. Electronic address: mirko.scordio@uniroma1.it.
  • Frasca F; Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185 Rome, Italy. Electronic address: federica.frasca@uniroma1.it.
  • Santinelli L; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Policlinico Umberto I of Rome, Viale del Policlinico 155, 00161 Rome, Italy. Electronic address: letizia.santinelli@uniroma1.it.
  • Sorrentino L; Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185 Rome, Italy. Electronic address: leonardo.sorrentino@uniroma1.it.
  • Pierangeli A; Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185 Rome, Italy. Electronic address: alessandra.pierangeli@uniroma1.it.
  • Turriziani O; Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185 Rome, Italy; Microbiology and Virology Unit, Sapienza University of Rome, Policlinico Umberto I of Rome, Viale Regina Elena, 324, 00161 Rome, Italy. Electronic address: ombret
  • Mastroianni CM; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Policlinico Umberto I of Rome, Viale del Policlinico 155, 00161 Rome, Italy. Electronic address: claudio.mastroianni@uniroma1.it.
  • Antonelli G; Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185 Rome, Italy; Microbiology and Virology Unit, Sapienza University of Rome, Policlinico Umberto I of Rome, Viale Regina Elena, 324, 00161 Rome, Italy. Electronic address: guido.
  • Viscidi RP; Department of Pediatrics, Johns Hopkins University School of Medicine, 1800 Orleans Street Baltimore, MD, United States. Electronic address: rviscid1@jhmi.edu.
  • d'Ettorre G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Policlinico Umberto I of Rome, Viale del Policlinico 155, 00161 Rome, Italy. Electronic address: gabriella.dettorre@uniroma1.it.
  • Scagnolari C; Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185 Rome, Italy. Electronic address: carolina.scagnolari@uniroma1.it.
Clin Immunol ; 241: 109068, 2022 08.
Article in English | MEDLINE | ID: covidwho-1906890
ABSTRACT
The presence of anti-IFN neutralizing antibodies (NAB) has been reported in critically ill COVID-19 patients. We found that 87.5% (7/8) of HIV-1 patients co-infected with SARS-CoV-2 had serum anti-IFN-I NAB against IFN-α subtypes, IFN-ß and/or IFN-ω. Anti-IFN-I NAB were also detected in oropharyngeal samples. Patients with NAB were males, and those with high serum anti-IFN-α/ω NAB titer had severe illness and exhibited reduction in the expression of IFN-stimulated genes. Thus, high titer of anti-IFN-α/ω NAB may contribute to the greater severity of COVID-19 in HIV-1 infected patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / HIV-1 / COVID-19 Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / HIV-1 / COVID-19 Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article