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Monoclonal antibodies binding data for SARS-CoV-2 proteins.
Mishra, Nawneet; Teyra, Joan; Boytz, RuthMabel; Miersch, Shane; Merritt, Trudy N; Cardarelli, Lia; Gorelik, Maryna; Mihalic, Filip; Jemth, Per; Davey, Robert A; Sidhu, Sachdev S; Leung, Daisy W; Amarasinghe, Gaya K.
  • Mishra N; Department of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, MO 63110, U.S.A.
  • Teyra J; The Donnelly Centre, University of Toronto, Toronto, Canada.
  • Boytz R; Department of Microbiology, Boston University School of Medicine, St Louis, MO 63110, U.S.A.
  • Miersch S; The Donnelly Centre, University of Toronto, Toronto, Canada.
  • Merritt TN; Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, U.S.A.
  • Cardarelli L; The Donnelly Centre, University of Toronto, Toronto, Canada.
  • Gorelik M; The Donnelly Centre, University of Toronto, Toronto, Canada.
  • Mihalic F; Department of Medical Biochemistry and Microbiology, Uppsala University, B.M.C. Box 582, Husargatan 3, 751 23 Uppsala Sweden.
  • Jemth P; Department of Medical Biochemistry and Microbiology, Uppsala University, B.M.C. Box 582, Husargatan 3, 751 23 Uppsala Sweden.
  • Davey RA; Department of Microbiology, Boston University School of Medicine, St Louis, MO 63110, U.S.A.
  • Sidhu SS; The Donnelly Centre, University of Toronto, Toronto, Canada.
  • Leung DW; Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, U.S.A.
  • Amarasinghe GK; Department of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, MO 63110, U.S.A.
Data Brief ; 43: 108415, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1906939
ABSTRACT
SARS-CoV-2 pandemic opens up the curiosity of understanding the coronavirus. This demand for the development of the regent, which can be used for academic and therapeutic applications. The present data provide the biochemical characterization of synthetically developed monoclonal antibodies for the SARS-CoV-2 proteins. The antibodies from phage-displayed antibody libraries were selected with the SARS-CoV-2 proteins immobilized in microwell plates. The clones which bind to the antigen in Fab-phage ELISA were selected, and a two-point competitive phage ELISA was performed. Antibodies binding kinetic of IgGs for SARS-CoV2 proteins further carried with B.L.I. Systematic analysis of binding with different control proteins and purified SARS-CoV-2 ensured the robustness of the antibodies.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Systematic review/Meta Analysis Language: English Journal: Data Brief Year: 2022 Document Type: Article Affiliation country: J.dib.2022.108415

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Systematic review/Meta Analysis Language: English Journal: Data Brief Year: 2022 Document Type: Article Affiliation country: J.dib.2022.108415