Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism.
Immunity
; 55(7): 1216-1233.e9, 2022 07 12.
Article
in English
| MEDLINE | ID: covidwho-1907207
ABSTRACT
Lung-resident memory B cells (MBCs) provide localized protection against reinfection in respiratory airways. Currently, the biology of these cells remains largely unexplored. Here, we combined influenza and SARS-CoV-2 infection with fluorescent-reporter mice to identify MBCs regardless of antigen specificity. We found that two main transcriptionally distinct subsets of MBCs colonized the lung peribronchial niche after infection. These subsets arose from different progenitors and were both class switched, somatically mutated, and intrinsically biased in their differentiation fate toward plasma cells. Combined analysis of antigen specificity and B cell receptor repertoire segregated these subsets into "bona fide" virus-specific MBCs and "bystander" MBCs with no apparent specificity for eliciting viruses generated through an alternative permissive process. Thus, diverse transcriptional programs in MBCs are not linked to specific effector fates but rather to divergent strategies of the immune system to simultaneously provide rapid protection from reinfection while diversifying the initial B cell repertoire.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Immunologic Memory
Limits:
Animals
Language:
English
Journal:
Immunity
Journal subject:
Allergy and Immunology
Year:
2022
Document Type:
Article
Affiliation country:
J.immuni.2022.06.002
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