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SARS-CoV-2 inactivation by ultraviolet radiation and visible light is dependent on wavelength and sample matrix.
Schuit, Michael A; Larason, Thomas C; Krause, Melissa L; Green, Brian M; Holland, Brian P; Wood, Stewart P; Grantham, Steven; Zong, Yuqin; Zarobila, Clarence J; Freeburger, Denise L; Miller, David M; Bohannon, Jordan K; Ratnesar-Shumate, Shanna A; Blatchley, Ernest R; Li, Xing; Dabisch, Paul A; Miller, C Cameron.
  • Schuit MA; National Biodefense Analysis and Countermeasures Center, Operated by Battelle National Biodefense Institute (BNBI) for the U.S. Department of Homeland Security (DHS) Science and Technology Directorate, 8300 Research Plaza, Frederick, MD 21702, USA. Electronic address: michael.schuit@st.dhs.gov.
  • Larason TC; National Institute of Standards and Technology (NIST), U.S. Department of Commerce (DoC), 100 Bureau Drive, Gaithersburg, MD 20899, USA.
  • Krause ML; National Biodefense Analysis and Countermeasures Center, Operated by Battelle National Biodefense Institute (BNBI) for the U.S. Department of Homeland Security (DHS) Science and Technology Directorate, 8300 Research Plaza, Frederick, MD 21702, USA.
  • Green BM; National Biodefense Analysis and Countermeasures Center, Operated by Battelle National Biodefense Institute (BNBI) for the U.S. Department of Homeland Security (DHS) Science and Technology Directorate, 8300 Research Plaza, Frederick, MD 21702, USA.
  • Holland BP; National Biodefense Analysis and Countermeasures Center, Operated by Battelle National Biodefense Institute (BNBI) for the U.S. Department of Homeland Security (DHS) Science and Technology Directorate, 8300 Research Plaza, Frederick, MD 21702, USA.
  • Wood SP; National Biodefense Analysis and Countermeasures Center, Operated by Battelle National Biodefense Institute (BNBI) for the U.S. Department of Homeland Security (DHS) Science and Technology Directorate, 8300 Research Plaza, Frederick, MD 21702, USA.
  • Grantham S; National Institute of Standards and Technology (NIST), U.S. Department of Commerce (DoC), 100 Bureau Drive, Gaithersburg, MD 20899, USA.
  • Zong Y; National Institute of Standards and Technology (NIST), U.S. Department of Commerce (DoC), 100 Bureau Drive, Gaithersburg, MD 20899, USA.
  • Zarobila CJ; National Institute of Standards and Technology (NIST), U.S. Department of Commerce (DoC), 100 Bureau Drive, Gaithersburg, MD 20899, USA.
  • Freeburger DL; National Biodefense Analysis and Countermeasures Center, Operated by Battelle National Biodefense Institute (BNBI) for the U.S. Department of Homeland Security (DHS) Science and Technology Directorate, 8300 Research Plaza, Frederick, MD 21702, USA.
  • Miller DM; National Biodefense Analysis and Countermeasures Center, Operated by Battelle National Biodefense Institute (BNBI) for the U.S. Department of Homeland Security (DHS) Science and Technology Directorate, 8300 Research Plaza, Frederick, MD 21702, USA.
  • Bohannon JK; National Biodefense Analysis and Countermeasures Center, Operated by Battelle National Biodefense Institute (BNBI) for the U.S. Department of Homeland Security (DHS) Science and Technology Directorate, 8300 Research Plaza, Frederick, MD 21702, USA.
  • Ratnesar-Shumate SA; National Biodefense Analysis and Countermeasures Center, Operated by Battelle National Biodefense Institute (BNBI) for the U.S. Department of Homeland Security (DHS) Science and Technology Directorate, 8300 Research Plaza, Frederick, MD 21702, USA.
  • Blatchley ER; Lyles School of Civil Engineering, Purdue University, 610 Purdue Mall, West Lafayette, IN, USA; Division of Environmental & Ecological Engineering, Purdue University, West Lafayette, IN 47907, USA.
  • Li X; Lyles School of Civil Engineering, Purdue University, 610 Purdue Mall, West Lafayette, IN, USA.
  • Dabisch PA; National Biodefense Analysis and Countermeasures Center, Operated by Battelle National Biodefense Institute (BNBI) for the U.S. Department of Homeland Security (DHS) Science and Technology Directorate, 8300 Research Plaza, Frederick, MD 21702, USA.
  • Miller CC; National Institute of Standards and Technology (NIST), U.S. Department of Commerce (DoC), 100 Bureau Drive, Gaithersburg, MD 20899, USA.
J Photochem Photobiol B ; 233: 112503, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1907356
ABSTRACT
Numerous studies have demonstrated that SARS-CoV-2 can be inactivated by ultraviolet (UV) radiation. However, there are few data available on the relative efficacy of different wavelengths of UV radiation and visible light, which complicates assessments of UV decontamination interventions. The present study evaluated the effects of monochromatic radiation at 16 wavelengths from 222 nm through 488 nm on SARS-CoV-2 in liquid aliquots and dried droplets of water and simulated saliva. The data were used to generate a set of action spectra which quantify the susceptibility of SARS-CoV-2 to genome damage and inactivation across the tested wavelengths. UVC wavelengths (≤280 nm) were most effective for inactivating SARS-CoV-2, although inactivation rates were dependent on sample type. Results from this study suggest that UV radiation can effectively inactivate SARS-CoV-2 in liquids and dried droplets, and provide a foundation for understanding the factors which affect the efficacy of different wavelengths in real-world settings.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies Limits: Humans Language: English Journal: J Photochem Photobiol B Journal subject: Biology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies Limits: Humans Language: English Journal: J Photochem Photobiol B Journal subject: Biology Year: 2022 Document Type: Article