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Risk of gout flares after COVID-19 vaccination: A case-crossover study.
Li, Hui; Dalbeth, Nicola; Wallace, Zachary S; Sparks, Jeffrey A; Li, Xiaoxiao; Zeng, Chao; Wang, Yilun; Xie, Dongxing; Lei, Guanghua; Wei, Jie; Zhang, Yuqing.
  • Li H; Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
  • Dalbeth N; Department of Medicine, University of Auckland, Auckland, New Zealand.
  • Wallace ZS; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; The Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Sparks JA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Li X; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China.
  • Zeng C; Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South Univ
  • Wang Y; Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
  • Xie D; Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
  • Lei G; Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South Univ
  • Wei J; Health Management Center, Xiangya Hospital, Central South University, Changsha, China; Department of Epidemiology and Health statistics, Xiangya School of Public Health, Central South University, Changsha, China. Electronic address: weij1988@csu.edu.cn.
  • Zhang Y; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; The Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: yzhang108@mgh.harvard.edu.
Semin Arthritis Rheum ; 56: 152059, 2022 10.
Article in English | MEDLINE | ID: covidwho-1907762
ABSTRACT

OBJECTIVE:

Routine vaccinations are associated with an increased risk of gout flares. We examined the association between COVID-19 vaccination, an immunization program implemented to a large proportion of population, and the risk of gout flares.

METHODS:

We conducted a time-stratified case-crossover study among patients with gout who experienced gout flares between December 2020 and September 2021, using data from The Health Improvement Network. We compared the risk of gout flares on each of the seven days on and after the day of COVID-19 vaccination vs. no vaccination during that period using conditional logistic regression. In addition, we performed subgroup analyses stratified by different COVID-19 vaccines (i.e., BNT162b2, hereafter referred to as BNT, and ChAdOx1 nCov-19, hereafter referred to as ChAd).

RESULTS:

Among 5,904 patients with gout (mean age 63·1 years; 85·5% male) who experienced gout flares within one month, the risk of gout flares slightly increased on the second day after COVID-19 vaccination (odds ratio 1·44; 95% CI 1·02 to 2·07). The risk of gout flares also slightly increased after receiving COVID-19 vaccine on other remaining days (ORs ranged from 1·03 to 1·22); however, none of them was statistically significant. An increased risk of gout flares on the second day after vaccination was mainly observed for the ChAd vaccine (odds ratio 1·44; 95% CI 1·00 to 2·05), but not for BNT vaccine (odds ratio 1·18; 95% CI 0·67 to 2·02).

CONCLUSION:

COVID-19 vaccination, mainly ChAd vaccination, slightly increases the risk of gout flares on the second day after vaccination. This finding reassures the safety of COVID-19 vaccination for patients with gout.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / Gout Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Female / Humans / Male / Middle aged Language: English Journal: Semin Arthritis Rheum Year: 2022 Document Type: Article Affiliation country: J.semarthrit.2022.152059

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / Gout Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Female / Humans / Male / Middle aged Language: English Journal: Semin Arthritis Rheum Year: 2022 Document Type: Article Affiliation country: J.semarthrit.2022.152059