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Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms.
Atyeo, Caroline G; Shook, Lydia L; Brigida, Sara; De Guzman, Rose M; Demidkin, Stepan; Muir, Cordelia; Akinwunmi, Babatunde; Baez, Arantxa Medina; Sheehan, Maegan L; McSweeney, Erin; Burns, Madeleine D; Nayak, Ruhi; Kumar, Maya K; Patel, Chinmay D; Fialkowski, Allison; Cvrk, Dana; Goldfarb, Ilona T; Yonker, Lael M; Fasano, Alessio; Balazs, Alejandro B; Elovitz, Michal A; Gray, Kathryn J; Alter, Galit; Edlow, Andrea G.
  • Atyeo CG; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Shook LL; PhD Program in Virology, Division of Medical Sciences, Harvard University, Boston, MA, USA.
  • Brigida S; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • De Guzman RM; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Demidkin S; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Muir C; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Akinwunmi B; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Baez AM; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Sheehan ML; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.
  • McSweeney E; Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Burns MD; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Nayak R; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Kumar MK; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Patel CD; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Fialkowski A; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • Cvrk D; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.
  • Goldfarb IT; Harvard Medical School, Boston, MA, USA.
  • Yonker LM; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Fasano A; Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Balazs AB; Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Elovitz MA; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Gray KJ; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • Alter G; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Edlow AG; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nat Commun ; 13(1): 3571, 2022 06 28.
Article in English | MEDLINE | ID: covidwho-1908170
ABSTRACT
The availability of three COVID-19 vaccines in the United States provides an unprecedented opportunity to examine how vaccine platforms and timing of vaccination in pregnancy impact maternal and neonatal immunity. Here, we characterize the antibody profile after Ad26.COV2.S, mRNA-1273 or BNT162b2 vaccination in 158 pregnant individuals and evaluate transplacental antibody transfer by profiling maternal and umbilical cord blood in 175 maternal-neonatal dyads. These analyses reveal lower vaccine-induced functions and Fc receptor-binding after Ad26.COV2.S compared to mRNA vaccination and subtle advantages in titer and function with mRNA-1273 versus BN162b2. mRNA vaccines have higher titers and functions against SARS-CoV-2 variants of concern. First and third trimester vaccination results in enhanced maternal antibody-dependent NK-cell activation, cellular and neutrophil phagocytosis, and complement deposition relative to second trimester. Higher transplacental transfer ratios following first and second trimester vaccination may reflect placental compensation for waning maternal titers. These results provide novel insight into the impact of platform and trimester of vaccination on maternal humoral immune response and transplacental antibody transfer.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Experimental Studies Topics: Vaccines / Variants Limits: Female / Humans / Infant, Newborn / Pregnancy Country/Region as subject: North America Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-31169-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Experimental Studies Topics: Vaccines / Variants Limits: Female / Humans / Infant, Newborn / Pregnancy Country/Region as subject: North America Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-31169-8