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A universal DNA aptamer as an efficient inhibitor against spike-protein/hACE2 interactions.
Silwal, Achut Prasad; Jahan, Raunak; Thennakoon, Siddhartha Kalpa Samadhi; Arya, Satya Prakash; Postema, Rick Mason; Vander Ark, Elizabeth Claire; Tan, Xiaohong.
  • Silwal AP; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio, 43403, USA. tanx@bgsu.edu.
  • Jahan R; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio, 43403, USA. tanx@bgsu.edu.
  • Thennakoon SKS; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio, 43403, USA. tanx@bgsu.edu.
  • Arya SP; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio, 43403, USA. tanx@bgsu.edu.
  • Postema RM; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio, 43403, USA. tanx@bgsu.edu.
  • Vander Ark EC; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio, 43403, USA. tanx@bgsu.edu.
  • Tan X; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio, 43403, USA. tanx@bgsu.edu.
Chem Commun (Camb) ; 58(58): 8049-8052, 2022 Jul 19.
Article in English | MEDLINE | ID: covidwho-1908311
ABSTRACT
A universal aptamer against spike-proteins of diverse SARS-CoV-2 variants was discovered via DNA SELEX towards the wild-type (WT) spike-protein. This aptamer, A1C1, binds to the WT spike-protein or other variants of concern such as Delta and Omicron with low nanomolar affinities. A1C1 inhibited the interaction between hACE2 and various spike-proteins by 85-89%. This universal A1C1 aptamer can be used to design diagnostic and therapeutic molecular tools to target SARS-CoV-2 and its variants.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Aptamers, Nucleotide / COVID-19 Topics: Variants Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: D2cc02647c

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Aptamers, Nucleotide / COVID-19 Topics: Variants Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: D2cc02647c