Monoclonal B-cell Lymphocytosis - a review of diagnostic criteria, biology, natural history, and clinical management.
Leuk Lymphoma
; 63(12): 2795-2806, 2022 Dec.
Article
in English
| MEDLINE | ID: covidwho-1908540
ABSTRACT
Since first described almost two decades ago, there has been significant evolution in our definition and understanding of the biology and implications of monoclonal B-cell lymphocytosis (MBL). This review provides an overview of the definition, classification, biology, and natural history of MBL, mainly focused on the dominant CLL-like phenotype form of MBL. The increasingly recognized implications of MBL with respect to immune dysfunction are discussed, particularly in view of the COVID-19 pandemic, along with management recommendations for MBL in the clinic.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Precancerous Conditions
/
Leukemia, Lymphocytic, Chronic, B-Cell
/
Neoplasms, Plasma Cell
/
COVID-19
/
Lymphocytosis
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Leuk Lymphoma
Journal subject:
Hematology
/
Neoplasms
Year:
2022
Document Type:
Article
Affiliation country:
10428194.2022.2092857
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