Ab-CoV: a curated database for binding affinity and neutralization profiles of coronavirus-related antibodies.
Bioinformatics
; 38(16): 4051-4052, 2022 Aug 10.
Article
in English
| MEDLINE | ID: covidwho-1908750
ABSTRACT
SUMMARY:
We have developed a database, Ab-CoV, which contains manually curated experimental interaction profiles of 1780 coronavirus-related neutralizing antibodies. It contains more than 3200 datapoints on half maximal inhibitory concentration (IC50), half maximal effective concentration (EC50) and binding affinity (KD). Each data with experimentally known three-dimensional structures are complemented with predicted change in stability and affinity of all possible point mutations of interface residues. Ab-CoV also includes information on epitopes and paratopes, structural features of viral proteins, sequentially similar therapeutic antibodies and Collier de Perles plots. It has the feasibility for structure visualization and options to search, display and download the data. AVAILABILITY AND IMPLEMENTATION Ab-CoV database is freely available at https//web.iitm.ac.in/bioinfo2/ab-cov/home. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Coronavirus
/
Antibodies, Viral
Type of study:
Prognostic study
Language:
English
Journal:
Bioinformatics
Journal subject:
Medical Informatics
Year:
2022
Document Type:
Article
Affiliation country:
Bioinformatics
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