The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study.
Int J Epidemiol
; 51(5): 1371-1383, 2022 10 13.
Article
in English
| MEDLINE | ID: covidwho-1908816
ABSTRACT
BACKGROUND:
Due to its large impact on human health, socio-economic status (SES) could at least partially influence the established association between obesity and coronavirus disease 2019 (COVID-19) severity. To estimate the independent effect of body size and SES on the clinical manifestations of COVID-19, we conducted a Mendelian randomization (MR) study.METHODS:
Applying two-sample MR approaches, we evaluated the effects of body mass index (BMI, n = 322â154), waist circumference (WC, n = 234â069), hip circumference (n = 213â019) and waist-hip ratio (n = 210â088) with respect to three COVID-19outcomes:
severe respiratory COVID-19 (cases = 8779, controls = 1â000â875), hospitalized COVID-19 (cases = 17â992, controls = 1â810â493) and COVID-19 infection (cases = 87â870, controls = 2â210â804). Applying a multivariable MR (MVMR) approach, we estimated the effect of these anthropometric traits on COVID-19 outcomes accounting for the effect of SES assessed as household income (n = 286â301).RESULTS:
BMI and WC were associated with severe respiratory COVID-19 [BMI odds ratio (OR) = 1.51, CI = 1.24-1.84, P = 3.01e-05; WC OR = 1.48, 95% CI = 1.15-1.91, P = 0.0019] and hospitalized COVID-19 (BMI OR = 1.50, 95% CI = 1.32-1.72, P = 8.83e-10; WC OR = 1.41, 95% CI = 1.20-1.67, P = 3.72e-05). Conversely, income was associated with lower odds of severe respiratory (OR = 0.70, 95% CI = 0.53-0.93, P = 0.015) and hospitalized COVID-19 (OR = 0.78, 95% CI = 0.66-0.92, P = 0.003). MVMR analyses showed that the effect of these obesity-related traits on increasing the odds of COVID-19 negative outcomes becomes null when accounting for income. Conversely, the association of income with lower odds of COVID-19 negative outcomes is not affected when including the anthropometric traits in the multivariable model.CONCLUSION:
Our findings indicate that SES contributes to the effect of obesity-related traits on COVID-19 severity and hospitalization.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Int J Epidemiol
Year:
2022
Document Type:
Article
Affiliation country:
Ije
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