Your browser doesn't support javascript.
The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study.
Cabrera-Mendoza, Brenda; Wendt, Frank R; Pathak, Gita A; De Angelis, Flavio; De Lillo, Antonella; Koller, Dora; Polimanti, Renato.
  • Cabrera-Mendoza B; Department of Psychiatry, Yale School of Medicine, West Haven, CT, USA.
  • Wendt FR; VA CT Healthcare System, West Haven, CT, USA.
  • Pathak GA; Department of Psychiatry, Yale School of Medicine, West Haven, CT, USA.
  • De Angelis F; VA CT Healthcare System, West Haven, CT, USA.
  • De Lillo A; Department of Psychiatry, Yale School of Medicine, West Haven, CT, USA.
  • Koller D; VA CT Healthcare System, West Haven, CT, USA.
  • Polimanti R; Department of Psychiatry, Yale School of Medicine, West Haven, CT, USA.
Int J Epidemiol ; 51(5): 1371-1383, 2022 10 13.
Article in English | MEDLINE | ID: covidwho-1908816
ABSTRACT

BACKGROUND:

Due to its large impact on human health, socio-economic status (SES) could at least partially influence the established association between obesity and coronavirus disease 2019 (COVID-19) severity. To estimate the independent effect of body size and SES on the clinical manifestations of COVID-19, we conducted a Mendelian randomization (MR) study.

METHODS:

Applying two-sample MR approaches, we evaluated the effects of body mass index (BMI, n = 322 154), waist circumference (WC, n = 234 069), hip circumference (n = 213 019) and waist-hip ratio (n = 210 088) with respect to three COVID-19

outcomes:

severe respiratory COVID-19 (cases = 8779, controls = 1 000 875), hospitalized COVID-19 (cases = 17 992, controls = 1 810 493) and COVID-19 infection (cases = 87 870, controls = 2 210 804). Applying a multivariable MR (MVMR) approach, we estimated the effect of these anthropometric traits on COVID-19 outcomes accounting for the effect of SES assessed as household income (n = 286 301).

RESULTS:

BMI and WC were associated with severe respiratory COVID-19 [BMI odds ratio (OR) = 1.51, CI = 1.24-1.84, P = 3.01e-05; WC OR = 1.48, 95% CI = 1.15-1.91, P = 0.0019] and hospitalized COVID-19 (BMI OR = 1.50, 95% CI = 1.32-1.72, P = 8.83e-10; WC OR = 1.41, 95% CI = 1.20-1.67, P = 3.72e-05). Conversely, income was associated with lower odds of severe respiratory (OR = 0.70, 95% CI = 0.53-0.93, P = 0.015) and hospitalized COVID-19 (OR = 0.78, 95% CI = 0.66-0.92, P = 0.003). MVMR analyses showed that the effect of these obesity-related traits on increasing the odds of COVID-19 negative outcomes becomes null when accounting for income. Conversely, the association of income with lower odds of COVID-19 negative outcomes is not affected when including the anthropometric traits in the multivariable model.

CONCLUSION:

Our findings indicate that SES contributes to the effect of obesity-related traits on COVID-19 severity and hospitalization.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Int J Epidemiol Year: 2022 Document Type: Article Affiliation country: Ije

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Int J Epidemiol Year: 2022 Document Type: Article Affiliation country: Ije