Cardiovascular outcome 6âmonths after severe coronavirus disease 2019 infection.
J Hypertens
; 40(7): 1278-1287, 2022 07 01.
Article
in English
| MEDLINE | ID: covidwho-1908998
ABSTRACT
OBJECTIVES:
In coronavirus disease 2019 (COVID-19), cardiovascular risk factors and myocardial injury relate to increased mortality. We evaluated the extent of cardiac sequelae 6âmonths after hospital discharge in patients surviving ICU hospitalization for COVID-19.METHODS:
All survivors of Maastricht-ICU were invited for comprehensive cardiovascular evaluation 6âmonths after discharge from ICU. Cardiac screening included an electrocardiogram, cardiac biomarkers, echocardiography, cardiac magnetic resonance (CMR) and, wherever indicated, cardiac computed tomography or coronary angiogram.RESULTS:
Out of 52 survivors, 81% ( n â=â42) participated to the cardiovascular follow-up [median follow-up of 6âmonths, interquartile range (IQR) 6.1-6.7]. Eight patients (19%) had newly diagnosed coronary artery disease (CAD), of which two required a percutaneous intervention. Echocardiographic global longitudinal strain (GLS) was abnormal in 24% and CMR-derived GLS was abnormal in 12%, despite normal left ventricular ejection fraction in all. None of the patients showed elevated T 1 relaxation times and five patients (14%) had an elevated T 2 relaxation time. Late gadolinium enhancement (LGE) reflecting regional myocardial fibrosis was increased in eight patients (21%), of which three had myocarditis and three had pericarditis.CONCLUSION:
Cardiovascular follow-up at 6âmonths after ICU-admission for severe COVID-19 revealed that one out of five invasively mechanically ventilated survivors had CAD, a quarter had subclinical left ventricular dysfunction defined as reduced echocardiographic GLS, and 42% of the patients had CMR abnormalities (reduced LVEF, reduced GLS, LGE presence, and elevated T 2 ). On the basis of these findings, long-term cardiovascular follow-up is strongly recommended in all post-IC COVID-19 patients. CLINICAL TRIAL REGISTRATION Trial Register number [NL8613]) https//www.trialregister.nl/trial/8613Video abstracthttp//links.lww.com/HJH/B899 .
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Coronary Artery Disease
/
COVID-19
Type of study:
Cohort study
/
Diagnostic study
/
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
J Hypertens
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS