Case fatality rate of the adult in-patients with COVID-19 and digestive system tumors: A systematic review and meta-analysis.
Medicine (Baltimore)
; 101(25): e29364, 2022 Jun 24.
Article
in English
| MEDLINE | ID: covidwho-1909029
ABSTRACT
BACKGROUND:
During the coronavirus disease 2019 (COVID-19) pandemic, endoscopic screening for gastrointestinal tumors was suspended or delayed in most countries. Thus, our study aimed to quantify the impact of COVID-19 on the clinical outcomes of patients with digestive system tumors through a systematic review and meta-analysis.METHODS:
We systematically searched the PubMed, Web of Science, Cochrane Library, and Embase databases as of March 7, 2021 to identify the case fatality rate (CFR) of COVID-19 patients diagnosed with digestive system tumors. A random-effects model was used for meta-analysis, I2 was used to assess heterogeneity, and funnel plot was used to assess publication bias.RESULTS:
A total of 13 studies were included, involving 2943 tumor patients with COVID-19, of which 871 were digestive system tumors, and the CFR was 24% (95% CI, 18%-30%; I2â=â55.7%). The mortality rate of colorectal cancer was 21% (95% CI, 14%-27%; I2â=â0.0%), gastric cancer was 25% (95% CI, 6%-45%; I2â=â0.0%), and hepatobiliary cancer was 29%. In general, there was no significant difference in the CFR of digestive system tumors.CONCLUSION:
The combined CFR of digestive system tumors and COVID-19 patients was 24%, which is much higher than that of the general population. Under the premise of fully complying with the international guidelines to limit the spread of COVID-19, we call for the resumption of endoscopic screening programs and selective surgery as soon as possible. REGISTRATION INFORMATION PROSPERO registration no. CRD42021248194.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
COVID-19
Type of study:
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Adult
/
Humans
Language:
English
Journal:
Medicine (Baltimore)
Year:
2022
Document Type:
Article
Affiliation country:
MD.0000000000029364
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