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Matched Versus Mixed COVID-19 Vaccinations in Korean Solid Organ Transplant Recipients: An Observational Study.
Kang, Ji-Man; Lee, Juhan; Huh, Kyu Ha; Joo, Dong Jin; Lee, Jae Geun; Kim, Hye Rim; Kim, Ha Yan; Lee, Myeongjee; Jung, Inkyung; Kim, Min Young; Kim, Sinyoung; Park, Younhee; Kim, Myoung Soo.
  • Kang JM; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, South Korea.
  • Lee J; Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea.
  • Huh KH; Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
  • Joo DJ; The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea.
  • Lee JG; Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
  • Kim HR; The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea.
  • Kim HY; Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
  • Lee M; The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea.
  • Jung I; Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
  • Kim MY; The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea.
  • Kim S; The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea.
  • Park Y; The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea.
  • Kim MS; The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea.
Transplantation ; 106(9): e392-e403, 2022 09 01.
Article in English | MEDLINE | ID: covidwho-1909078
ABSTRACT

BACKGROUND:

Solid organ transplant recipients (SOTRs) are vulnerable to severe coronavirus disease 2019 (COVID-19) and exhibit poor antibody responses to COVID-19 vaccines. Herein, we compared the humoral immunogenicity of a mixed vaccine (ChAdOx1 nCoV-19 [ChAd]/BNT162b2 [BNT]) with that of conventional matched vaccines (mRNA, adenoviral vector [AdV-Vec]) in SOTRs.

METHODS:

Serum samples were collected at Severance Hospital (Seoul, Korea) between September and October 2021 (14 d-5 mo after COVID-19 vaccination; V2). The severe acute respiratory syndrome coronavirus 2 antispike IgG titer (BAU/mL; ELISA) and neutralization inhibition (percentage; neutralization assay) were compared between vaccination groups overall and stratified by V2 (poststudy vaccination visit) timing.

RESULTS:

Of the 464 participants, 143 (31%) received mRNA vaccines, 170 (37%) received AdV-Vec vaccines, and 151 (33%) received mixed vaccines (all ChAd/BNT). The geometric mean titer for the ChAd/BNT group was 3.2-fold higher than that of the AdV-Vec group (geometric mean ratio, 3.2; confidence interval, 1.9-5.4) but lower than that of the mRNA group (geometric mean ratio, 0.4; confidence interval, 0.2-0.7). Neutralization inhibition in the ChAd/BNT group was 32%, which was higher than that in the AdV-Vec group (21%; P < 0.001) but lower than that in the mRNA group (55%; P = 0.02). There was no difference in geometric mean titer by V2 timing (ChAd/BNT, 45 versus 31, days 14-60; mRNA, 28 versus 15, days 61-150).

CONCLUSIONS:

The ChAd/BNT group showed higher humoral immunogenicity than the AdV-Vec group, with similar immunogenicity to the mRNA vaccine. Nevertheless, immunogenicity following the primary vaccination series was poor in all vaccine groups, supporting the justification for booster vaccination in SOTRs.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Transplant Recipients / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal: Transplantation Year: 2022 Document Type: Article Affiliation country: Tp.0000000000004241

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Transplant Recipients / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal: Transplantation Year: 2022 Document Type: Article Affiliation country: Tp.0000000000004241