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Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers - the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol.
Wallace, Sarah; Hall, Victoria; Charlett, Andre; Kirwan, Peter D; Cole, Michele; Gillson, Natalie; Atti, Ana; Timeyin, Jean; Foulkes, Sarah; Taylor-Kerr, Andrew; Andrews, Nick; Shrotri, Madhumita; Rokadiya, Sakib; Oguti, Blanche; Vusirikala, Amoolya; Islam, Jasmin; Zambon, Maria; Brooks, Tim J G; Ramsay, Mary; Brown, Colin S; Chand, Meera; Hopkins, Susan.
  • Wallace S; National Infection Service, UK Health Security Agency, London, UK.
  • Hall V; National Infection Service, UK Health Security Agency, London, UK Victoria.Hall@phe.gov.uk.
  • Charlett A; Statistics, Modelling and Economics Unit, UK Health Security Agency, London, UK.
  • Kirwan PD; National Infection Service, UK Health Security Agency, London, UK.
  • Cole M; MRC Biostatistics Unit, Cambridge, UK.
  • Gillson N; National Infection Service, UK Health Security Agency, London, UK.
  • Atti A; National Infection Service, UK Health Security Agency, London, UK.
  • Timeyin J; National Infection Service, UK Health Security Agency, London, UK.
  • Foulkes S; National Infection Service, UK Health Security Agency, London, UK.
  • Taylor-Kerr A; National Infection Service, UK Health Security Agency, London, UK.
  • Andrews N; National Infection Service, UK Health Security Agency, London, UK.
  • Shrotri M; Statistics, Modelling and Economics Unit, UK Health Security Agency, London, UK.
  • Rokadiya S; National Infection Service, UK Health Security Agency, London, UK.
  • Oguti B; National Infection Service, UK Health Security Agency, London, UK.
  • Vusirikala A; National Infection Service, UK Health Security Agency, London, UK.
  • Islam J; National Infection Service, UK Health Security Agency, London, UK.
  • Zambon M; National Infection Service, UK Health Security Agency, London, UK.
  • Brooks TJG; National Infection Service, UK Health Security Agency, London, UK.
  • Ramsay M; National Infection Service, UK Health Security Agency, London, UK.
  • Brown CS; National Infection Service, UK Health Security Agency, London, UK.
  • Chand M; National Infection Service, UK Health Security Agency, London, UK.
  • Hopkins S; National Infection Service, UK Health Security Agency, London, UK.
BMJ Open ; 12(6): e054336, 2022 06 28.
Article in English | MEDLINE | ID: covidwho-1909750
ABSTRACT

INTRODUCTION:

Understanding the effectiveness and durability of protection against SARS-CoV-2 infection conferred by previous infection and COVID-19 is essential to inform ongoing management of the pandemic. This study aims to determine whether prior SARS-CoV-2 infection or COVID-19 vaccination in healthcare workers protects against future infection. METHODS AND

ANALYSIS:

This is a prospective cohort study design in staff members working in hospitals in the UK. At enrolment, participants are allocated into cohorts, positive or naïve, dependent on their prior SARS-CoV-2 infection status, as measured by standardised SARS-CoV-2 antibody testing on all baseline serum samples and previous SARS-CoV-2 test results. Participants undergo monthly antibody testing and fortnightly viral RNA testing during follow-up and based on these results may move between cohorts. Any results from testing undertaken for other reasons (eg, symptoms, contact tracing) or prior to study entry will also be captured. Individuals complete enrolment and fortnightly questionnaires on exposures, symptoms and vaccination. Follow-up is 12 months from study entry, with an option to extend follow-up to 24 months.The primary outcome of interest is infection with SARS-CoV-2 after previous SARS-CoV-2 infection or COVID-19 vaccination during the study period. Secondary outcomes include incidence and prevalence (both RNA and antibody) of SARS-CoV-2, viral genomics, viral culture, symptom history and antibody/neutralising antibody titres. ETHICS AND DISSEMINATION The study was approved by the Berkshire Research Ethics Committee, Health Research Authority (IRAS ID 284460, REC reference 20/SC/0230) on 22 May 2020; the vaccine amendment was approved on 12 January 2021. Participants gave informed consent before taking part in the study.Regular reports to national and international expert advisory groups and peer-reviewed publications ensure timely dissemination of findings to inform decision making. TRIAL REGISTRATION NUMBER ISRCTN11041050.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Country/Region as subject: Europa Language: English Journal: BMJ Open Year: 2022 Document Type: Article Affiliation country: Bmjopen-2021-054336

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Country/Region as subject: Europa Language: English Journal: BMJ Open Year: 2022 Document Type: Article Affiliation country: Bmjopen-2021-054336