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Bicarbonate concentration as a predictor of prognosis in moderately severe COVID-19 patients: A multicenter retrospective study.
Sada, Ken-Ei; Yamamoto, Ryohei; Yano, Akihiko; Miyauchi, Atsushi; Kawamura, Masafumi; Ito, Hideki.
  • Sada KE; Department of Clinical Epidemiology, Kochi Medical School, Kochi University, Nankoku, Japan.
  • Yamamoto R; Department of Internal Medicine, Kochi Prefectural Hata-Kenmin Hospital, Sukumo, Japan.
  • Yano A; Department of General Medicine, Kochi Health Sciences Center, Kochi, Japan.
  • Miyauchi A; Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Kawamura M; Department of General Medicine, Kochi Health Sciences Center, Kochi, Japan.
  • Ito H; Department of Internal Medicine, Kochi Prefectural Hata-Kenmin Hospital, Sukumo, Japan.
PLoS One ; 17(6): e0270141, 2022.
Article in English | MEDLINE | ID: covidwho-1910671
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) patients reportedly have high bicarbonate concentration. However, its relationship to the disease progression are obscure.

METHODS:

In this two-center retrospective study, we included COVID-19 patients with moderate severity between March 2020 and May 2021. We classified patients into three groups according to bicarbonate concentrations high (>27 mEq/L), normal (21 to 27 mEq/L), and low (<21 mEq/L). The primary outcome was the time to clinical worsening defined by the requirement of intubation or death during 90 days. We evaluated high or low bicarbonate concentration during the clinical course related to the primary outcome using multivariable Cox proportional hazard models.

RESULTS:

Of the 60 participants (median age 72 years), 60% were men. Participants were classified into high (13 patients), normal (30 patients), and low (17 patients) groups. Clinical worsening occurred in 54% of patients in the high group, 23% in the normal group, and 65% in the low group. Both high and low groups were associated with a higher clinical worsening rate HR, 3.02 (95% CI, 1.05 to 8.63) in the high group; 3.49 (95% CI 1.33 to 9.12) in the low group.

CONCLUSION:

Monitoring of bicarbonate concentrations may be useful to predict the prognosis.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Bicarbonates / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0270141

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bicarbonates / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0270141