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Ischemic stroke in patients that recover from COVID-19: Comparisons to historical stroke prior to COVID-19 or stroke in patients with active COVID-19 infection.
Akhtar, Naveed; Abid, Fatma; Singh, Rajvir; Kamran, Saadat; Imam, Yahia; Al-Jerdi, Salman; Salamah, Sarah; Al Attar, Rand; Yasir, Muhammad; Shabir, Hammad; Morgan, Deborah; Joseph, Sujatha; AlMaslamani, Muna; Shuaib, Ashfaq.
  • Akhtar N; The Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
  • Abid F; Infectious Diseases Section, Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Singh R; Cardiology Research, Hamad Medical Corporation, Doha, Qatar.
  • Kamran S; The Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
  • Imam Y; The Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
  • Al-Jerdi S; Weill Cornell Medical College, Doha, Qatar.
  • Salamah S; Infectious Diseases Section, Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Al Attar R; Infectious Diseases Section, Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Yasir M; Emergency Department, Hamad Medical Corporation, Doha, Qatar.
  • Shabir H; Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Morgan D; The Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
  • Joseph S; The Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
  • AlMaslamani M; Infectious Diseases Section, Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Shuaib A; University of Alberta, Edmonton, Alberta, Canada.
PLoS One ; 17(6): e0270413, 2022.
Article in English | MEDLINE | ID: covidwho-1910681
ABSTRACT
BACKGROUND AND

PURPOSE:

Understanding the relationship of COVID-19 to stroke is important. We compare characteristics of pre-pandemic historical stroke (Pre-C), cases in acute COVID infection (Active-C) and in patients who have recovered from COVID-19 infection (Post-C).

METHODS:

We interrogated the Qatar stroke database for all stroke admissions between Jan 2019 and Feb 2020 (Pre-C) to Active-C (Feb2020-Feb2021) and Post-C to determine how COVID-19 affected ischemic stroke sub-types, clinical course, and outcomes prior to, during and post-pandemic peak. We used the modified Rankin Scale (mRS) to measure outcome at 90-days (mRS 0-2 good recovery and mRS 3-6 as poor recovery). For the current analysis, we compared the clinical features and prognosis in patients with confirmed acute ischemic stroke.

RESULTS:

There were 1413 cases admitted (pre-pandemic 1324, stroke in COVID-19 46 and recovered COVID-19 stroke 43). Patients with Active-C were significantly younger, had more severe symptoms, fever on presentation, more ICU admissions and poor stroke recovery at discharge when compared to Pre-C and Post-C. Large vessel disease and cardioembolic disease was significantly more frequent in Active-C compared to PRE-C or post-C.

CONCLUSIONS:

Stroke in Post-C has characteristics similar to Pre-C with no evidence of lasting effects of the virus on the short-term. However, Active-C is a more serious disease and tends to be more severe and have a poor prognosis.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Ischemia / Stroke / Ischemic Stroke / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0270413

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Ischemia / Stroke / Ischemic Stroke / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0270413