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Health Impairments in Children and Adolescents After Hospitalization for Acute COVID-19 or MIS-C.
Maddux, Aline B; Berbert, Laura; Young, Cameron C; Feldstein, Leora R; Zambrano, Laura D; Kucukak, Suden; Newhams, Margaret M; Miller, Kristen; FitzGerald, Madyson M; He, Jie; Halasa, Natasha B; Cvijanovich, Natalie Z; Loftis, Laura L; Walker, Tracie C; Schwartz, Stephanie P; Gertz, Shira J; Tarquinio, Keiko M; Fitzgerald, Julie C; Kong, Michele; Schuster, Jennifer E; Mack, Elizabeth H; Hobbs, Charlotte V; Rowan, Courtney M; Staat, Mary A; Zinter, Matt S; Irby, Katherine; Crandall, Hillary; Flori, Heidi; Cullimore, Melissa L; Nofziger, Ryan A; Shein, Steven L; Gaspers, Mary Glas; Hume, Janet R; Levy, Emily R; Chen, Sabrina R; Patel, Manish M; Tenforde, Mark W; Weller, Edie; Campbell, Angela P; Randolph, Adrienne G.
  • Maddux AB; Department of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.
  • Berbert L; Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA.
  • Young CC; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, MA.
  • Feldstein LR; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA.
  • Zambrano LD; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA.
  • Kucukak S; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, MA.
  • Newhams MM; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, MA.
  • Miller K; Department of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.
  • FitzGerald MM; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, MA.
  • He J; Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA.
  • Halasa NB; Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.
  • Cvijanovich NZ; Division of Critical Care Medicine, UCSF Benioff Children's Hospital Oakland, CA.
  • Loftis LL; Section of Critical Care Medicine, Department of Pediatrics, Texas Children's Hospital, Houston, TX.
  • Walker TC; Department of Pediatrics, University of North Carolina at Chapel Hill Children's Hospital, Chapel Hill, NC.
  • Schwartz SP; Department of Pediatrics, University of North Carolina at Chapel Hill Children's Hospital, Chapel Hill, NC.
  • Gertz SJ; Division of Pediatric Critical Care, Department of Pediatrics, Cooperman Barnabas Medical Center, Livingston, NJ.
  • Tarquinio KM; Division of Critical Care Medicine, Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA.
  • Fitzgerald JC; Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Kong M; Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
  • Schuster JE; Division of Pediatric Infectious Disease, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MO.
  • Mack EH; Division of Pediatric Critical Care Medicine, Medical University of South Carolina, Charleston, SC.
  • Hobbs CV; Department of Pediatrics, Division of Disease; Microbiology; University of Mississippi Medical Center, Jackson, MS.
  • Rowan CM; Division of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN.
  • Staat MA; Department of Pediatrics, University of Cincinnati, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
  • Zinter MS; Department of Pediatrics, Division of Critical Care, University of California San Francisco, San Francisco, CA.
  • Irby K; Section of Pediatric Critical Care, Department of Pediatrics, Arkansas Children's Hospital, Little Rock, AR.
  • Crandall H; Division of Pediatric Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, UT.
  • Flori H; Division of Pediatric Critical Care Medicine, Department of Pediatrics, Mott Children's Hospital and University of Michigan, Ann Arbor, MI.
  • Cullimore ML; Division of Pediatric Critical Care, Department of Pediatrics, Children's Hospital and Medical Center, Omaha, NE.
  • Nofziger RA; Division of Critical Care Medicine, Akron Children's Hospital, Akron, OH.
  • Shein SL; Division of Pediatric Critical Care Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH.
  • Gaspers MG; University of Arizona, Diamond Children's Banner Children's Medical Center, Tucson, AZ.
  • Hume JR; Division of Pediatric Critical Care, University of Minnesota Masonic Children's Hospital, Minneapolis, MN.
  • Levy ER; Divisions of Pediatric Infectious Diseases and Pediatric Critical Care Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
  • Chen SR; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, MA.
  • Patel MM; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA.
  • Tenforde MW; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA.
  • Weller E; Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA.
  • Campbell AP; Department of Pediatrics, Harvard Medical School, Boston, MA.
  • Randolph AG; COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA.
Pediatrics ; 2022 06 29.
Article in English | MEDLINE | ID: covidwho-1910743
ABSTRACT

OBJECTIVE:

To evaluate risk factors for post-discharge sequelae in children and adolescents after hospitalization for acute COVID-19 or multisystem inflammatory syndrome in children (MIS-C).

METHODS:

Multicenter prospective observational cohort study conducted in 25 US pediatric hospitals. Patients <21-years-old, hospitalized May 2020 to May 2021 for acute COVID-19 or MIS-C with follow-up 2-4 months after admission. We assessed readmissions, caregiver-reported persistent symptoms or activity impairment, and new morbidities identified by the Functional Status Scale. Multivariable regression was used to calculate adjusted risk ratios (aRR).

RESULTS:

Of 358 eligible patients, 2-4 month survey data were available for 119/155 (76.8%) with acute COVID-19 and 160/203 (78.8%) with MIS-C. Thirteen (11%) patients with acute COVID-19 and 12 (8%) with MIS-C had a readmission. Thirty-two (26.9%) patients with acute COVID-19 had persistent symptoms (22.7%) or activity impairment (14.3%) and 48 (30.0%) patients with MIS-C had persistent symptoms (20.0%) or activity impairment (21.3%). For patients with acute COVID-19, persistent symptoms (aRR, 1.29[95% CI, 1.04-1.59]) and activity impairment (aRR, 1.37[95% CI, 1.06-1.78]) were associated with more organs systems involved. Patients with MIS-C and pre-existing respiratory conditions more frequently had persistent symptoms (aRR, 3.09[95% CI, 1.55-6.14]) and those with obesity more frequently had activity impairment (aRR, 2.52[95% CI, 1.35-4.69]). New morbidities were infrequent (9% COVID-19 and 1% MIS-C).

CONCLUSIONS:

Over one in four children hospitalized with acute COVID-19 or MIS-C experienced persistent symptoms or activity impairment for at least 2 months. Patients with MIS-C and respiratory conditions or obesity are at higher risk of prolonged recovery.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Risk factors Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: Peds.2022-057798

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Risk factors Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: Peds.2022-057798