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Memory elicitation, T-cell response and antibody production: an independent study of an inactivated entire virus vaccine (Coronavac).
Souza-Silva, Guilherme Antonio DE; Aquino, Rodrigo Cesar A DE; Sousa, Georon F DE; Barros, Bárbara Rafaela S; Lima, Maríllia Raphaella C F DE; Cruz, Leonardo C O; Marcos, Bianca F São; Silva, Anna Jéssica D; Tales, Aparecida Virgínia S; Diniz, Madi V; Lima, Mônica Maria C; Sá, Igor W A DE; Rodrigues, Fábio Augusto C; Souza, Edson B DE; Nascimento, Arione V DO; Vieira, Amanda M; Carvalho, Bruno M DE; Campelo Júnior, Evônio B; Freitas, Antonio Carlos DE; Melo, Cristiane M L DE.
  • Souza-Silva GA; Federal University of Pernambuco, Laboratory of Immunological and Antitumor Analysis, Department of Antibiotics, Bioscience Center, Av. Prof. Artur de Sá, s/n, Cidade Universitária, 50740-525 Recife, PE, Brazil.
  • Aquino RCA; Federal University of Pernambuco, Keizo Asami Immunopathology Laboratory (LIKA), Avenida Professor Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
  • Sousa GF; Federal University of Pernambuco, Laboratory of Immunological and Antitumor Analysis, Department of Antibiotics, Bioscience Center, Av. Prof. Artur de Sá, s/n, Cidade Universitária, 50740-525 Recife, PE, Brazil.
  • Barros BRS; Federal University of Pernambuco, Keizo Asami Immunopathology Laboratory (LIKA), Avenida Professor Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
  • Lima MRCF; Federal University of Pernambuco, Laboratory of Immunological and Antitumor Analysis, Department of Antibiotics, Bioscience Center, Av. Prof. Artur de Sá, s/n, Cidade Universitária, 50740-525 Recife, PE, Brazil.
  • Cruz LCO; Federal University of Pernambuco, Keizo Asami Immunopathology Laboratory (LIKA), Avenida Professor Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
  • Marcos BFS; Federal University of Pernambuco, Laboratory of Immunological and Antitumor Analysis, Department of Antibiotics, Bioscience Center, Av. Prof. Artur de Sá, s/n, Cidade Universitária, 50740-525 Recife, PE, Brazil.
  • Silva AJD; Federal University of Pernambuco, Keizo Asami Immunopathology Laboratory (LIKA), Avenida Professor Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
  • Tales AVS; Federal University of Pernambuco, Laboratory of Immunological and Antitumor Analysis, Department of Antibiotics, Bioscience Center, Av. Prof. Artur de Sá, s/n, Cidade Universitária, 50740-525 Recife, PE, Brazil.
  • Diniz MV; Federal University of Pernambuco, Laboratory of Immunological and Antitumor Analysis, Department of Antibiotics, Bioscience Center, Av. Prof. Artur de Sá, s/n, Cidade Universitária, 50740-525 Recife, PE, Brazil.
  • Lima MMC; Federal University of Pernambuco, Laboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Bioscience Center, Avenida Reitor Joaquim Amazonas, s/n, Cidade Universitária, 50740-570, Recife, PE, Brazil.
  • Sá IWA; Federal University of Pernambuco, Laboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Bioscience Center, Avenida Reitor Joaquim Amazonas, s/n, Cidade Universitária, 50740-570, Recife, PE, Brazil.
  • Rodrigues FAC; Federal University of Pernambuco, Clinical Hospital, Avenida Professor Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
  • Souza EB; Federal University of Pernambuco, Clinical Hospital, Avenida Professor Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
  • Nascimento AVD; Federal University of Pernambuco, Clinical Hospital, Avenida Professor Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
  • Vieira AM; Federal University of Pernambuco, Clinical Hospital, Avenida Professor Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
  • Carvalho BM; Federal University of Pernambuco, Clinical Hospital, Avenida Professor Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
  • Campelo Júnior EB; Federal University of Pernambuco, Clinical Hospital, Avenida Professor Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
  • Freitas AC; Federal University of Pernambuco, Clinical Hospital, Avenida Professor Moraes Rego, 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
  • Melo CML; University of Pernambuco, Institute of Biological Sciences, Rua Arnóbio Marquês, 310, Santo Amaro, 50100-130 Recife, PE, Brazil.
An Acad Bras Cienc ; 94(3): e20211590, 2022.
Article in English | MEDLINE | ID: covidwho-1910746
ABSTRACT
Health professionals working to mitigate the COVID-19 pandemic are one of the main risk groups for the disease, being prioritized for vaccination. Considering this, the aim of this study was to analyze the immune response of these professionals immunized with CoronaVac in the first and second doses. Blood samples were collected after the first and second doses of the vaccine (CoronaVac) and used to investigate hematological and biochemical parameters, analysis of immunoglobulin production, cytokines, and gene expression profile, as well as the identification of subsets of immune cells. Post-first dose immunological phenotypic memory (CD27+) profiles (T CD4+, TCD8+ and CD19+) showed a significant increase, as did Monocyte APCs (CD80+HLA-DR+) in relation to the second dose. The cytokines IL-2, IL-6 and IFN-° showed increased values in relation to the other analyzed cytokines. The Th2/Th17 profile in the second dose was characterized by gene expression analysis. The production of IgM and IgG after vaccination showed statistically significant values in the comparison between doses. CoronaVac showed activation of APCs monocytes, memory response of T and B lymphocytes, with immunoglobulins production. This set of responses is characterized by the Th2/Th17 immunological profile.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Antibody Formation Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: An Acad Bras Cienc Year: 2022 Document Type: Article Affiliation country: 0001-3765202220211590

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Antibody Formation Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: An Acad Bras Cienc Year: 2022 Document Type: Article Affiliation country: 0001-3765202220211590