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The Interactions among Hypertension, Cancer, and COVID-19: Perspective with Regard to Ca2+/cAMP Signalling.
Bergantin, Leandro Bueno.
  • Bergantin LB; Department of Pharmacology, Universidade Federal de São Paulo, Escola Paulista de Medicina, Laboratory of Autonomic and Cardiovascular Pharmacology, 55 11 5576-4973, Rua Pedro de Toledo, 669, Vila Clementino, São Paulo, SP, Brazil.
Curr Cancer Drug Targets ; 22(5): 351-360, 2022.
Article in English | MEDLINE | ID: covidwho-1910830
ABSTRACT

BACKGROUND:

The hypothesis that hypertension is clinically associated with an enhanced risk of developing cancer has been highlighted. However, the working principles involved in this link are still under intensive discussion. A correlation among inflammation, hypertension, and cancer could accurately describe the clinical link between these diseases. In addition, dyshomeostasis of Ca2+ has been considered to be involved in both cancer and hypertension, and inflammation. There is a strong link between Ca2+ signalling, e.g. enhanced Ca2+ signals, and inflammatory outcomes. cAMP also modulates pro- and anti-inflammatory outcomes; pharmaceuticals, which increase intracellular cAMP levels, can decrease the production of proinflammatory mediators and enhance the production of antiinflammatory outcomes.

OBJECTIVE:

This article highlights the participation of Ca2+/cAMP signalling in the clinical association among inflammation, hypertension, and an enhanced risk for the development of cancer. In addition, considering that research on coronavirus disease 2019 (COVID-19) is a rapidly evolving field, this article also reviews recent reports related to the role of Ca2+ channel blockers in restoring Ca2+ signalling disruption due to COVID-19, including the relationship among COVID-19, cancer, and hypertension.

CONCLUSION:

An understanding of the association among these diseases could expand current pharmacotherapy, involving Ca2+ channel blockers and pharmaceuticals that facilitate a rise in cAMP levels.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hypertension / Neoplasms Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Curr Cancer Drug Targets Journal subject: Antineoplastic agents / Neoplasms Year: 2022 Document Type: Article Affiliation country: 1568009622666220215143805

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hypertension / Neoplasms Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Curr Cancer Drug Targets Journal subject: Antineoplastic agents / Neoplasms Year: 2022 Document Type: Article Affiliation country: 1568009622666220215143805