Association between the COVID-19 pandemic and pertussis derived from multiple nationwide data sources, France, 2013 to 2020.
Euro Surveill
; 27(25)2022 06.
Article
in English
| MEDLINE | ID: covidwho-1910958
ABSTRACT
BackgroundInterventions to mitigate the COVID-19 pandemic may impact other respiratory diseases.AimsWe aimed to study the course of pertussis in France over an 8-year period including the beginning of the COVID-19 pandemic and its association with COVID-19 mitigation strategies, using multiple nationwide data sources and regression models.MethodsWe analysed the number of French pertussis cases between 2013 and 2020, using PCR test results from nationwide outpatient laboratories (Source 1) and a network of the paediatric wards from 41 hospitals (Source 2). We also used reports of a national primary care paediatric network (Source 3). We conducted a quasi-experimental interrupted time series analysis, relying on negative binomial regression models. The models accounted for seasonality, long-term cycles and secular trend, and included a binary variable for the first national lockdown (start 16 March 2020).ResultsWe identified 19,039 pertussis cases from these data sources. Pertussis cases decreased significantly following the implementation of mitigation measures, with adjusted incidence rate ratios of 0.10 (95% CI 0.04-0.26) and 0.22 (95% CI 0.07-0.66) for Source 1 and Source 2, respectively. The association was confirmed in Source 3 with a medianâ¯of, respectively, one (IQR 0-2) and 0 cases (IQR 0-0) per month before and after lockdown (p = 0.0048).ConclusionsThe strong reduction in outpatient and hospitalised pertussis cases suggests an impact of COVID-19 mitigation measures on pertussis epidemiology. Pertussis vaccination recommendations should be followed carefully, and disease monitoring should be continued to detect any resurgence after relaxation of mitigation measures.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Whooping Cough
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Child
/
Humans
Country/Region as subject:
Europa
Language:
English
Journal subject:
Communicable Diseases
Year:
2022
Document Type:
Article
Affiliation country:
1560-7917.ES.2022.27.25.2100933
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