Global dynamics of SARS-CoV-2/malaria model with antibody immune response.
Math Biosci Eng
; 19(8): 8380-8410, 2022 06 09.
Article
in English
| MEDLINE | ID: covidwho-1911810
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a new viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Malaria is a parasitic disease caused by Plasmodium parasites. In this paper, we explore a within-host model of SARS-CoV-2/malaria coinfection. This model consists of seven ordinary differential equations that study the interactions between uninfected red blood cells, infected red blood cells, free merozoites, uninfected epithelial cells, infected epithelial cells, free SARS-CoV-2 particles, and antibodies. We show that the model has bounded and nonnegative solutions. We compute all steady state points and derive their existence conditions. We use appropriate Lyapunov functions to confirm the global stability of all steady states. We enhance the reliability of the theoretical results by performing numerical simulations. The steady states reflect the monoinfection and coinfection with malaria and SARS-CoV-2. The shared immune response reduces the concentrations of malaria merozoites and SARS-CoV-2 particles in coinfected patients. This response reduces the severity of SARS-CoV-2 infection in this group of patients.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Coinfection
/
COVID-19
/
Malaria
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Math Biosci Eng
Year:
2022
Document Type:
Article
Affiliation country:
Mbe.2022390
Similar
MEDLINE
...
LILACS
LIS