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Heterologous high dose SARS-CoV-2 mRNA vaccine booster may improve immune response in seronegative kidney transplant recipients.
Tylicki, Leszek; Biedunkiewicz, Bogdan; Slizien, Zuzanna; Muchlado, Marta; Debska-Slizien, Alicja.
  • Tylicki L; Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
  • Biedunkiewicz B; Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
  • Slizien Z; Medical students of the Medical University of Gdansk, Gdansk, Poland.
  • Muchlado M; Medical students of the Medical University of Gdansk, Gdansk, Poland.
  • Debska-Slizien A; Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
Arch Med Sci ; 18(4): 1100-1102, 2022.
Article in English | MEDLINE | ID: covidwho-1911941
ABSTRACT

Introduction:

Three-dose mRNA vaccination against COVID-19 is unable to elicit a sufficient immune response in immunocompromised subjects.

Methods:

The aim of the study was to conduct a retrospective evaluation of the efficacy of a heterologous mRNA booster with mRNA-1273 in constantly seronegative kidney transplant recipients (KTRs) after three doses of the BNT162b2 mRNA vaccine. Twelve seronegative KTRs received a mRNA-1273 booster 5 months after the third dose of BNT162b2.

Results:

A total of 5 out of 12 patients (41.7%) seroconverted, with a mean titer of 353 BAU/ml.

Conclusions:

The administration of a heterologous mRNA vaccine as a booster may be an effective alternative for achieving post-vaccination immunity in seronegative KTRs.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study Topics: Vaccines Language: English Journal: Arch Med Sci Year: 2022 Document Type: Article Affiliation country: Aoms

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study Topics: Vaccines Language: English Journal: Arch Med Sci Year: 2022 Document Type: Article Affiliation country: Aoms