Factors associated to risk of death among COVID patients hospitalized in low-intensity care unit: a real-life experience
Italian Journal of Medicine
; 16(SUPPL 1):42, 2022.
Article
in English
| EMBASE | ID: covidwho-1913096
ABSTRACT
Background:
Second wave of SARS-CoV-2 pandemic showed a devastating impact in term of absolute mortality, higher than observed in the first wave. Objective of the study was to evaluate factors associated with mortality among COVID patients in hospital setting. Materials andMethods:
We retrospectively evaluated clinical data, SARS-CoV-2 E and N2 genes expression on nasal swab and outcomes of patients hospitalized for COVID pneumonia in a lowintensity medical care unit during the second wave of pandemic.Results:
We evaluated 163 patients (64,4% M, 35,6% F), mean age 69,6±14 years, Decease was observed in 11,7% of cases. A significant higher mortality was present in patients with diabetes (p=0,027;OR 2,91), hematologic diseases (p=0,002;OR 7,4) and cirrhosis (p<0,0001). Remdesivir was the only treatment associated with a lower mortality (p=0,01, OR 0,5). Deceased patients showed a longer duration of symptoms before hospitalization (p=0,032) and lower levels of arterial oxygen tension (pO2) at the admission (p=0,22). Lower admission pO2 levels showed a good accuracy to identify patients who deceased (AUC=0,73, p=0,022), with an optimal cut-off of pO2<45 mmHg (Sns 77%, Spc 81%). An inverse relation between oxygen saturation and gene E (R=-0,28;p=0,009) and N2 (R=-0,36;p=0,003) expression was present.Conclusions:
Several factors may stratify the risk of death in patients with COVID pneumonia, including comorbidities, pO2 at the admission and levels of viral replication. A pO2<45 mmHg detected in the emergency department may identify patients with higher risk of death. Remdesivir treatment was associated with a lower mortality.
remdesivir; aged; arterial oxygen tension; clinical evaluation; comorbidity; conference abstract; controlled study; coronavirus disease 2019; diabetic patient; emergency ward; female; gene expression; hematologic disease; hospitalization; human; liver cirrhosis; major clinical study; male; medical care; mortality; nonhuman; nose smear; outcome assessment; oxygen saturation; pandemic; personal experience; pneumonia; retrospective study; Severe acute respiratory syndrome coronavirus 2; virus replication
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Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
English
Journal:
Italian Journal of Medicine
Year:
2022
Document Type:
Article
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