Your browser doesn't support javascript.
Factors associated to risk of death among COVID patients hospitalized in low-intensity care unit: a real-life experience
Italian Journal of Medicine ; 16(SUPPL 1):42, 2022.
Article in English | EMBASE | ID: covidwho-1913096
ABSTRACT

Background:

Second wave of SARS-CoV-2 pandemic showed a devastating impact in term of absolute mortality, higher than observed in the first wave. Objective of the study was to evaluate factors associated with mortality among COVID patients in hospital setting. Materials and

Methods:

We retrospectively evaluated clinical data, SARS-CoV-2 E and N2 genes expression on nasal swab and outcomes of patients hospitalized for COVID pneumonia in a lowintensity medical care unit during the second wave of pandemic.

Results:

We evaluated 163 patients (64,4% M, 35,6% F), mean age 69,6±14 years, Decease was observed in 11,7% of cases. A significant higher mortality was present in patients with diabetes (p=0,027;OR 2,91), hematologic diseases (p=0,002;OR 7,4) and cirrhosis (p<0,0001). Remdesivir was the only treatment associated with a lower mortality (p=0,01, OR 0,5). Deceased patients showed a longer duration of symptoms before hospitalization (p=0,032) and lower levels of arterial oxygen tension (pO2) at the admission (p=0,22). Lower admission pO2 levels showed a good accuracy to identify patients who deceased (AUC=0,73, p=0,022), with an optimal cut-off of pO2<45 mmHg (Sns 77%, Spc 81%). An inverse relation between oxygen saturation and gene E (R=-0,28;p=0,009) and N2 (R=-0,36;p=0,003) expression was present.

Conclusions:

Several factors may stratify the risk of death in patients with COVID pneumonia, including comorbidities, pO2 at the admission and levels of viral replication. A pO2<45 mmHg detected in the emergency department may identify patients with higher risk of death. Remdesivir treatment was associated with a lower mortality.
Keywords
Search on Google
Collection: Databases of international organizations Database: EMBASE Type of study: Prognostic study Language: English Journal: Italian Journal of Medicine Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS

Search on Google
Collection: Databases of international organizations Database: EMBASE Type of study: Prognostic study Language: English Journal: Italian Journal of Medicine Year: 2022 Document Type: Article