Extreme hyperferritinemia in the pediatric emergency setting: haemophagocytic lymphohistiocytosis, macrophage activation syndrome, sepsis and more
Journal of Biological Regulators and Homeostatic Agents
; 36(1):129-133, 2022.
Article
in English
| Web of Science | ID: covidwho-1913219
ABSTRACT
Ferritin plays an important role in modulating inflammation and is a significant marker in some life-threatening pathological conditions. Hemophagocytic lymphohistiocytosis (HLH), macrophage activation syndrome (MAS), sepsis, and the more recent multisystem inflammatory syndrome in children (MIS-C) share many clinical and laboratory aspects, including the increase in ferritin levels, so that they are considered hyperferritinemic syndromes. In the pediatric emergency setting, the finding of high ferritin levels if associated with fever requires considering these rare syndromes to start a timely therapy.
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Collection:
Databases of international organizations
Database:
Web of Science
Language:
English
Journal:
Journal of Biological Regulators and Homeostatic Agents
Year:
2022
Document Type:
Article
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