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Risk assessment in COVID-19: Prognostic importance of cardiovascular parameters.
Zdanyte, Monika; Martus, Peter; Nestele, Jeremy; Bild, Alexander; Mizera, Lars; Glatthaar, Andreas; Petersen Uribe, Álvaro; Emschermann, Frederic; Henes, Jessica-Kristin; Geisler, Tobias; Müller, Karin; Gawaz, Meinrad; Rath, Dominik.
  • Zdanyte M; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Martus P; Institute for Clinical Epidemiology and Applied Biostatistics, University Hospital Tübingen, Tübingen, Germany.
  • Nestele J; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Bild A; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Mizera L; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Glatthaar A; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Petersen Uribe Á; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Emschermann F; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Henes JK; Eberhard-Karls-Universität Tübingen, Geschwister-Scholl-Platz, Tübingen, Germany.
  • Geisler T; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Müller K; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Gawaz M; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Rath D; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
Clin Cardiol ; 45(9): 943-951, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1913774
ABSTRACT

BACKGROUND:

Cardiovascular risk factors and comorbidities are highly prevalent among COVID-19 patients and are associated with worse outcomes.

HYPOTHESIS:

We therefore investigated if established cardiovascular risk assessment models could efficiently predict adverse outcomes in COVID-19. Furthermore, we aimed to generate novel risk scores including various cardiovascular parameters for prediction of short- and midterm outcomes in COVID-19.

METHODS:

We included 441 consecutive patients diagnosed with SARS-CoV-2 infection. Patients were followed-up for 30 days after the hospital admission for all-cause mortality (ACM), venous/arterial thromboembolism, and mechanical ventilation. We further followed up the patients for post-COVID-19 syndrome for 6 months and occurrence of myocarditis, heart failure, acute coronary syndrome (ACS), and rhythm events in a 12-month follow-up. Discrimination performance of DAPT, GRACE 2.0, PARIS-CTE, PREDICT-STABLE, CHA2-DS2-VASc, HAS-BLED, PARIS-MB, PRECISE-DAPT scores for selected endpoints was evaluated by ROC-analysis.

RESULTS:

Out of established risk assessment models, GRACE 2.0 score performed best in predicting combined endpoint and ACM. Risk assessment models including age, cardiovascular risk factors, echocardiographic parameters, and biomarkers, were generated and could successfully predict the combined endpoint, ACM, venous/arterial thromboembolism, need for mechanical ventilation, myocarditis, ACS, heart failure, and rhythm events. Prediction of post-COVID-19 syndrome was poor.

CONCLUSION:

Risk assessment models including age, laboratory parameters, cardiovascular risk factors, and echocardiographic parameters showed good discrimination performance for adverse short- and midterm outcomes in COVID-19 and outweighed discrimination performance of established cardiovascular risk assessment models.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thromboembolism / Acute Coronary Syndrome / COVID-19 / Heart Failure / Myocarditis Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Clin Cardiol Year: 2022 Document Type: Article Affiliation country: Clc.23883

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thromboembolism / Acute Coronary Syndrome / COVID-19 / Heart Failure / Myocarditis Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Clin Cardiol Year: 2022 Document Type: Article Affiliation country: Clc.23883